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TranscriptomicsAcyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development
Gene expression profiling in non tumor lesion in the liver of patients prior to administering peretinoin was unrelated to the clinical outcome, however, gene expression profiling 8 weeks after starting peretinoin therapy significantly predicted the recurrence of HCC Peretinoin, a member of the acycl...
ORGANISM(S): Homo sapiens 
2012-08-19 | E-GEOD-29302 | biostudies-arrayexpress
TranscriptomicsNon-cancerous liver infiltrating lymphocytes of hepatitis C and tumor-infiltrating lymphocytes
Study goal is to disclose features of gene expressio profile of non-cancerous liver-infiltrating lymphocytes of type C hepatitis patients with hepatocellular carcinomas and tumor-infiltrating lymphocytes of type C hepatitis patients with hepatocellular carcinomas. Keywords: gene expression profile,...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-10461 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of hepatitis B- and hepatitis C-related hepatocellular carcinoma using graphical Gaussian modeling
Gene expression profiling of hepatocellular carcinoma (HCC) and background liver has been studied extensively; however, the relationship between the gene expression profiles of different lesions has not been assessed. We examined the expression profiles of 34 HCC specimens (17 hepatitis B virus [HBV...
ORGANISM(S): Homo sapiens 
2013-11-14 | E-GEOD-44074 | biostudies-arrayexpress
TranscriptomicsMicroRNA-27a regulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells
Gene expression profiling was carried out in Huh-7.5 cells in which miR-27a was over- or under-expressed. Transfection of cells with pre-miR-27a and pre-miR-control, or anti-miR-27a and anti-miR-control enabled down- and up-regulated genes to be determined, respectively. Replication and infectivity ...
ORGANISM(S): Homo sapiens 
2013-06-05 | E-GEOD-41737 | biostudies-arrayexpress
TranscriptomicsSerial gene expression profiling in the liver of Pdgf-c Tg mice that developed hepatic fibrosis and tumors
Over expression of PDGF-C in mouse liver resulted in the progression of hepatic fibrosis, steatosis and the development of HCC; this mouse model closely resembles the human HCC that is frequently associated with hepatic fibrosis. Peretinoin (generic name; code, NIK-333), developed by the Kowa Compan...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-31431 | biostudies-arrayexpress
TranscriptomicsGene expression annalysis of peripheral blood cells in patients with chronic kidney disease
Genes related to sleep and wakefulness were evaluated by RNA microarray in patients, including CKD,HD patients and control subjects. RNA microarray analysis was performed in 19 patients without diabetes. The patients were divided into three groups: HT group (8 hypertension patients with eGFR of >60 ...
ORGANISM(S): Homo sapiens 
2015-07-07 | E-GEOD-70528 | biostudies-arrayexpress
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