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MetabolomicsSnail reprograms glucose metabolism by repressing PFKP allowing cancer cell survival under metabolic stress
Dynamic regulation of glucose flux between aerobic glycolysis and the pentose phosphate pathway (PPP) during epithelial-mesenchymal transition (EMT) is not well-understood. Here we show that Snail (SNAI1), a key transcriptional repressor of EMT, regulates glucose flux toward PPP, allowing cancer cel...
2017-11-07 | MTBLS387 | MetaboLights
TranscriptomicsGene expression in human endometrial cancer tissues and serous papillary endometrial cancer cell line, SPAC-1L, treated by STAT1-siRNA and/or IFN-gamma
Endometrial cancer is one of the most common gynecologic malignancies, and patients with high grade disease, especially serous papillary subtype (SPEC) are often related to the poor outcomes. Recent genome-wide analyses have revealed that SPEC exhibits gene expression profiles that are distinct from...
ORGANISM(S): Homo sapiens 
2014-03-20 | E-GEOD-56026 | biostudies-arrayexpress
TranscriptomicsExpression data from the comparison between CD8 single positive (SP) thymocytes of CIITAtgpIV-/- mouse and B6 WT mouse
Thymocyte-thymocyte interaction can be very efficiently occur in CIITAtgpIV-/- mouse. We analyzed the gene expression profile between CD8+ T cells generated in CIITAtgpIV-/- mouse, and compared it to that of CD8+ T cells from B6 WT mouse. In this dataset, we include the expression data obtained from...
ORGANISM(S): Mus musculus 
2010-12-18 | E-GEOD-26090 | biostudies-arrayexpress
UnknownComparative Genomics and Virulence Mechanisms to Identify Genes Related to Mucin O-Glycan Degradation and Pathogenicity in a Potentially Multidrug-Resistant Clostridium tertium Strain.
Not available
S-EPMC12641198 | biostudies-literature
UnknownDiagnostic performance and clinical feasibility of a novel one-step RT-qPCR assay for simultaneous detection of multiple severe acute respiratory syndrome coronaviruses.
Not available
S-EPMC8885489 | biostudies-literature
TranscriptomicsTranscriptome analysis in Mycobacterium leprae (M. leprae)-infected granuloma of BALB/c nu/nu mice
Our object is to characterize the distinguish gene enrichment group in skin of Mycobacterium leprae (M. leprae)-infected footpads compared to that of Mycobacterium leprae (M. leprae) non-infected footpads. One-condition experiment, Skin of M. leprae non-infected footpads (control) vs. Skin of M. lep...
ORGANISM(S): Mus musculus 
2011-03-17 | E-GEOD-24120 | biostudies-arrayexpress
ProteomicsDependency of NELF-E-KAT2B epigenetic axis in breast cancer carcinogenesis
Cancer cells undergo transcriptional reprogramming to drive tumor progression and metastasis. Here, we identified the transcriptional complex, NELF (Negative elongation factor), as an important regulator of this process. Using cancer cell lines and patient-derived tumor organoids, we demonstrated th...
ORGANISM(S): Homo Sapiens (human) 
2023-01-28 | PXD031304 | JPOST Repository
TranscriptomicsmRNA expression profile in vascular smooth muscle cells (VSMCs) after inducing calcification
Vascular calcification (VC) is often associated with cardiovascular and metabolic diseases. However, the molecular mechanisms linking VC to these diseases have yet to be elucidated. Here we report that MDM2-induced polyubiquitination of histone deacetylase 1 (HDAC1) mediates VC. Loss of HDAC1 activi...
ORGANISM(S): Rattus norvegicus 
2015-11-07 | E-GEOD-74755 | biostudies-arrayexpress
UnknownCo-degradation of interferon signaling factor DDX3 by PB1-F2 as a basis for high virulence of 1918 pandemic influenza
Not available
S-SCDT-EMBOJ-2018-99475 | biostudies-other
UnknownCommon non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium.
Not available
S-EPMC4204770 | biostudies-literature
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