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UnknownA novel method for prokaryotic promoter prediction based on DNA stability.
Not available
S-EPMC545949 | biostudies-literature
GenomicsGenome-wide identification of functional elements regulated by T-bet and GATA3 in human T-cells
T-bet and GATA3 induce differentiation of CD4+ T-cells into Th1 or Th2 effectors. These exhibit a range of different properties but understanding of T-bet and GATA3 function is mostly limited to the murine Ifng and Il4/Il5/Il13 loci. We hypothesised that extending such analyses across the human geno...
ORGANISM(S): Homo sapiens 
2012-11-16 | E-GEOD-31320 | biostudies-arrayexpress
GenomicsGenome-wide regulatory analysis reveals T-bet controls Th17 lineage differentiation through direct suppression of IRF4
The complex relationship between Th1 and Th17 cells is incompletely understood. The transcription factor T-bet is best known as the master regulator of Th1 lineage commitment. However, attention is now focused on the repression of alternate T cell subsets mediated by T-bet, particularly the Th17 lin...
ORGANISM(S): Mus musculus 
2013-12-03 | E-GEOD-40623 | biostudies-arrayexpress
GenomicsModulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs epigenetic reprogramming
Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes deregulated by specific combinations of these EBNAs thr...
ORGANISM(S): Homo sapiens 
2013-09-13 | E-GEOD-47629 | biostudies-arrayexpress
GenomicsThe 7SK small nuclear ribonucleoprotein links the cell responses to transcription and replication stress by promoting replication fork reversal and homologous recombination
The 7SK small nuclear ribonucleoprotein links the cell responses to transcription and replication stress by promoting replication fork reversal and homologous recombination
PRJNA1336697 | ENA
GenomicsPI3K-AKT activation determines oncogenic RAS-induced hypertranscription and replication stress [ChrRNAseq]
PI3K-AKT activation determines oncogenic RAS-induced hypertranscription and replication stress [ChrRNAseq]
PRJNA1430363 | ENA
GenomicsPI3K-AKT activation determines oncogenic RAS-induced hypertranscription and replication stress [RNASeq]
PI3K-AKT activation determines oncogenic RAS-induced hypertranscription and replication stress [RNASeq]
PRJNA1430365 | ENA
GenomicsHuman RNaseH2 subunit upregulation counteracts oncogene- and chemotherapy-induced replication stress
Human RNaseH2 subunit upregulation counteracts oncogene- and chemotherapy-induced replication stress
PRJNA1158243 | ENA
UnknownA Novel Form of JARID2 is Required for Differentiation in Lineage-Committed Cells
Not available
S-SCDT-84488_2_1543572876_jats | biostudies-other
TranscriptomicsT-bet and GATA-3 act in combination through distal regulatory elements across the genome
Gene expression measurements in Thp, Th1 and Th2 cells polarised from naIve CD4+ T-cells isolated from wildtype and T-bet fl/fl x Cd4-Cre BALB/c mice or from WT and Gata-3 fl/fl x Tnfrsf4-Cre C57BL/6 mice.
ORGANISM(S): Mus musculus 
2012-10-29 | E-TABM-1187 | biostudies-arrayexpress
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