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GenomicsGenome-wide regulatory analysis reveals T-bet controls Th17 lineage differentiation through direct suppression of IRF4
The complex relationship between Th1 and Th17 cells is incompletely understood. The transcription factor T-bet is best known as the master regulator of Th1 lineage commitment. However, attention is now focused on the repression of alternate T cell subsets mediated by T-bet, particularly the Th17 lin...
ORGANISM(S): Mus musculus 
2013-12-03 | E-GEOD-40623 | biostudies-arrayexpress
GenomicsPI3K-AKT activation determines oncogenic RAS-induced hypertranscription and replication stress [ChrRNAseq]
PI3K-AKT activation determines oncogenic RAS-induced hypertranscription and replication stress [ChrRNAseq]
PRJNA1430363 | ENA
GenomicsPI3K-AKT activation determines oncogenic RAS-induced hypertranscription and replication stress [RNASeq]
PI3K-AKT activation determines oncogenic RAS-induced hypertranscription and replication stress [RNASeq]
PRJNA1430365 | ENA
TranscriptomicsT-bet and GATA-3 act in combination through distal regulatory elements across the genome
Gene expression measurements in Thp, Th1 and Th2 cells polarised from naIve CD4+ T-cells isolated from wildtype and T-bet fl/fl x Cd4-Cre BALB/c mice or from WT and Gata-3 fl/fl x Tnfrsf4-Cre C57BL/6 mice.
ORGANISM(S): Mus musculus 
2012-10-29 | E-TABM-1187 | biostudies-arrayexpress
TranscriptomicsDownregulation of integrin receptor signalling genes by EBV EBNA 3C
Comparsion of cellular gene expression between a control B lymphoma cell-line (BJAB pz2) stably transfected with an empty vector and a BJAB cell-line stably expressing Epstein-Barr virus EBNA 3C (BJAB E3C-4). These cell lines are described in Wang, F., C. Gregory, C. Sample, M. Rowe, D. Liebowitz, R...
ORGANISM(S): Homo sapiens 
2012-03-13 | E-MEXP-3585 | biostudies-arrayexpress
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