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TranscriptomicsAberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome
Somatic mutations in the spliceosome gene ZRSR2 (located on the X chromosome) are associated with myelodysplastic syndrome (MDS). ZRSR2 is involved in the recognition of 3' splice site during the early stages of spliceosome assembly; however, its precise role in RNA splicing has remained unclear. He...
ORGANISM(S): Homo sapiens 
2015-01-15 | E-GEOD-63816 | biostudies-arrayexpress
TranscriptomicsAnaplastic thyroid carcinoma cell lines (HTH83 and TL3) infected with LAMC2 shRNA
Laminin-5 gamma-2 (LAMC2) is highly expressed in anaplastic thyroid carcinoma and associated with tumor progression, migration and invasion by modulating signaling of EGFR LAMC2 was highly expressed in ATC samples and cell lines compared to normal thyroid tissues. Silencing LAMC2 by shRNA in ATC cel...
ORGANISM(S): Homo sapiens 
2013-10-10 | E-GEOD-50767 | biostudies-arrayexpress
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