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TranscriptomicsMapping of nascent RNA in MLL2 F/F and FC/FC MEF cells
Global Run-On has been performed in MLL2 F/F and FC/FC MEF cells. The aim of the experiment is to test how the lack of MLL2 affects nascent RNA transcription. Four samples were analyzed - 2 independent replicates. The experiments were performed using immortalized mouse embryonic fibroblasts (MEF) in...
ORGANISM(S): Mus musculus 
2016-04-13 | E-GEOD-73126 | biostudies-arrayexpress
TranscriptomicsGenome wide profiling of the RNAPII, γH2AX, H3K4Me1, H3K4M2 and H3K4Me3 in MLL2 F/F and FC/FC MEF cells
We investigated the RNAPII and γH2AX occupancy genome wide by ChIP-Seq in MLL2 F/F and FC/FC80 MEF cells. We found that a week after MLL2 excision (FC/FC cells), a group of genes present higher levels of γH2AX and RNAPII near the TSS, as compared to the control (F/F cells). H3K4Me1, H3K4M2 and H3...
ORGANISM(S): Mus musculus 
2016-04-13 | E-GEOD-73124 | biostudies-arrayexpress
GenomicsMutations in histone and other genes in MLL2-impaired human and mouse cells
We used human or mouse MLL2-impaired cells (including a human DSET MLL2 cell line,) as well as their parental controls, and measured mutations in histones and a few other genes that were affected in our gH2AX ChIP-Seq experiments. We found that cells lacking or having impaired MLL2 were presenting s...
ORGANISM(S): Mus musculus 
2016-04-13 | E-GEOD-73128 | biostudies-arrayexpress
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