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TranscriptomicsThe NOD/SCID Xenograft Model Provides Clinically-Relevant Insights into Glucocorticoid-Induced Gene Expression in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia
Introduction. Glucocorticoids are critical drugs used to treat acute lymphoblastic leukemia, and response to glucocorticoids is highly predictive of outcome. Here we report a study evaluating the NOD/SCID xenograft mouse model to investigate glucocorticoid-induced gene expression. Methods. NOD/SCID ...
ORGANISM(S): Homo sapiens 
2011-11-28 | E-GEOD-30392 | biostudies-arrayexpress
UnknownEarly innate immunity determines outcome of Mycobacterium tuberculosis pulmonary infection in rabbits.
Not available
S-EPMC3765177 | biostudies-literature
TranscriptomicsAn early inflammatory gene profile in visceral adipose tissue in children
The aim of this study was to characterize expression profiles of visceral and subcutaneous adipose tissue in children. Adipose tissue samples were collected from children having elective surgery (n=71, [54 boys], 6.0 +- 4.3 years). Affymetrix microarrays (n=20) were performed to characterize the fun...
ORGANISM(S): Homo sapiens 
2011-06-04 | E-GEOD-29718 | biostudies-arrayexpress
UnknownLong-Term HIV Pre-Exposure Prophylaxis Persistence and Reinitiation in Connecticut from 2012 to 2018.
Not available
S-EPMC11698670 | biostudies-literature
UnknownEthnicity and outcome of young breast cancer patients in the United Kingdom: the POSH study.
Not available
S-EPMC3887284 | biostudies-literature
TranscriptomicsReduced Retinal Microvascular Density, Improvement in Forepaw Reach, Comparative Microarray and Gene Set Enrichment Analysis using DNA Enzyme Targeting c-jun mRNA
Retinal neovascularization is a critical component in the pathogenesis of common ocular disorders that cause blindness, and treatment options are limited. We evaluated the therapeutic effect of a DNA enzyme targeting c-jun mRNA in mice with pre-existing retinal neovascularization. A single injection...
ORGANISM(S): Mus musculus 
2012-05-10 | E-GEOD-37898 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human adipose tissue from hypopituitary men before and after growth hormon (GH) treatment.
Adipose tissue is a major target of GH action. GH stimulates lipolysis and reduces fat mass. The molecular mechanism underlying cellular and metabolic effects of GH in adipose tissue is not well understood. The aim of this study is to identify GH-responsive genes that regulate lipid metabolism in ad...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-MTAB-276 | biostudies-arrayexpress
TranscriptomicsWhite Matter transcriptome in chronic alcoholism
Chronic alcohol consumption can lead to alchohol-related brain damage (ARBD). Despite the well known acute effects of alcohol the mechanism responsible for chronic brain damage is largely unknown. Pathologically the major change is the loss of white matter while neuronal loss is mild and restricted ...
ORGANISM(S): Homo sapiens 
2014-01-04 | E-GEOD-53808 | biostudies-arrayexpress
UnknownMeasurement of SARS-CoV-2 RNA in wastewater tracks community infection dynamics.
Not available
S-EPMC8325066 | biostudies-literature
UnknownTreatment of Dupuytren Contracture Recurrence After Surgery With Collagenase Clostridium Histolyticum: A Retrospective Multicenter Series
Not available
S-EPMC12859253 | biostudies-literature
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