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TranscriptomicsMaternal diabetes alters transcriptional programs in the developing embryo.
Exposure to maternal diabetes during pregnancy alters transcriptional profiles in the developing embryo. The enrichment, within the set of de-regulated genes, of those encoding transcriptional regulatory molecules provides support for the hypothesis that maternal diabetes affects specific developme...
ORGANISM(S): Mus musculus 
2012-09-25 | E-GEOD-41095 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in hypothalamus of non-recombinant subcongenic-derived F2 mice fed macronutrient selection diets
The specific genes influencing the quantitative variation in macronutrient preference and food intake are virtually unknown. We refined a previously identified mouse chromosome 17 (MMU17) region harboring quantitative trait loci (QTL) with large effects on preferential macronutrient intake-carbohyd...
ORGANISM(S): Mus musculus 
2015-05-15 | E-GEOD-60756 | biostudies-arrayexpress
TranscriptomicsAltered Gene Expression in Placentae from a Mouse Model of Diabetic Pregnancy
AIMS/HYPOTHESIS: Pregnancies complicated by diabetes have a higher risk of adverse outcomes for mothers and children, including predisposition to disease later in life, such as metabolic syndrome and hypertension. We hypothesized that adverse outcomes from diabetic pregnancies may be linked to comp...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-28277 | biostudies-arrayexpress
TranscriptomicsGenotype modulates gene expression profiles in the uterus in response to preconceptual folate supplementation.
Periconceptual supplementation of women with folate is considered a great success for public health. Higher folate status, either by supplementation, or via the mandatory fortification of grain products in the United States, has lead to significant reduction in the incidence of neural tube defects. ...
ORGANISM(S): Mus musculus 
2013-03-31 | E-GEOD-36974 | biostudies-arrayexpress
TranscriptomicsGene expression in teratogenic exposures: a new approach to understanding individual risk
The phenomenon of partial or incomplete penetrance is common to many paradigms of exposure to teratogens, where only some of the exposed individuals exhibit developmental defects. We here argue that the most widely used experimental approaches in reproductive toxicology do not take partial penetranc...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-50600 | biostudies-arrayexpress
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