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TranscriptomicsTranscription profiling of mouse Abl pre-B cell lines with conditional deletion of dicer
Abelson virus (v-Abl)-transformed pre-B cell lines from BM of dcrfl/fl; R26R-yfp (4470; 4475) and dcrfl/+; R26R-yfp mice (4483) are treated with a transducible Cre protein (Tat-Cre) to induce deletion of the dicer-1 gene in vitro. Cre activity is conveniently monitored by concomitant expression of Y...
ORGANISM(S): Mus musculus 
2008-03-08 | E-MEXP-1455 | biostudies-arrayexpress
UnknownClass switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors.
Not available
S-EPMC2082107 | biostudies-literature
MetabolomicsMapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan
Polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) hybrid systems typically use complex protein-protein interactions to facilitate direct transfer of intermediates between these multimodular megaenzymes. In the canal-associated neurons (CANs) of Caenorhabditis elegans, PKS-1 and NR...
2021-06-22 | MTBLS2313 | MetaboLights
MetabolomicsThe Impacts of Sortase A and the 4'-Phosphopantetheinyl Transferase Homolog Sfp on Streptococcus mutans Extracellular Membrane Vesicle Biogenesis

Extracellular membrane vesicles (EMVs) are produced by many Gram-positive organisms, but information regarding vesiculogenesis is incomplete. We used single gene deletions to evaluate the impacts on Streptococcus mutans EMV biogenesis of Sortase A (SrtA), which affects S. mutans...

2021-10-06 | MTBLS1812 | MetaboLights
UnknownFalse lumen/true lumen wall pressure ratio is increased in acute non-A non-B aortic dissection.
Not available
S-EPMC9486891 | biostudies-literature
TranscriptomicsAnalysis of the global gene expression in VEGF-B transgenic rat hearts
We show that an excess of VEGF-B protects the heart via adaptive cardiac hypertrophy and increased coronary arterial reserve, and by inducing a shift from lipid to glucose metabolism. Six VEGF-B overexpressing transgenic hearts were compared to six littermate wildtype controls
ORGANISM(S): Rattus norvegicus 
2013-11-30 | E-GEOD-38454 | biostudies-arrayexpress
UnknownMethanodibenzo[b,f][1,5]dioxocins as Novel Glutaminase Inhibitor with Anti-Glioblastoma Potential.
Not available
S-EPMC9954004 | biostudies-literature
MetabolomicsFeatures of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficit...
2024-01-12 | MTBLS850 | MetaboLights
TranscriptomicsAnalysis of the global gene expression in the rat hearts transduced with adeno-associated viral vectors coding VEGF-B
We show that an excess of VEGF-B protects the heart via adaptive cardiac hypertrophy and increased coronary arterial reserve, and by inducing a shift from lipid to glucose metabolism. Six hearts transduced with AAV-VEGF-B were compared to six AAV-HSA (human serum albumin) controls
ORGANISM(S): Rattus norvegicus 
2013-11-30 | E-GEOD-38455 | biostudies-arrayexpress
UnknownProduction of IgG autoantibody requires expression of activation-induced deaminase in early-developing B cells in a mouse model of SLE.
Not available
S-EPMC4197127 | biostudies-literature
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