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TranscriptomicsEffect of pharmacological inhibition of ASBT on bile composition and sclerosing cholangitis in mdr2 knockout mice
We report the effect of a potent pharmacological inhibition of ASBT in mdr2 -/- mice, compared to genetic and treatment controls using RNA-sequencing. Through quantification of mRNA in liver samples, we found significant upregulation of anti-inflammatory and anti-fibrotic gene signatures in mdr2-/-...
ORGANISM(S): Mus musculus 
2016-02-17 | E-GEOD-66231 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of the ileum following vertical sleeve gastrectomy compared to pair-fed sham surgery controls in mice with high-fat diet-induced obesity.
We report the expression profiles of ileal samples extracted from obese male C57Bl6 mice following vertical sleeve gastrectomy or sham surgery, focusing of gene signatures indicative of altered bile acid metabolism. We induced obesity in male C57bl6 mice through a high-fat diet. At 8 weeks, they we...
ORGANISM(S): Mus musculus 
2014-03-27 | E-GEOD-53782 | biostudies-arrayexpress
TranscriptomicsTranscriptomic characterization of the impact of 2'-fucosyllactose supplementation on intestinal adaptation following ileocecal resection.
Purpose: To identify the impact of 2'-FL supplementation on adaptive response following extensive intestinal resection. Methods: Transcriptomic profiles were obtained from mice undergoing ileocecal recection (8-10 week old male mice) and again at 8 weeks post-surgery. At the time of resection and...
ORGANISM(S): Mus musculus 
2016-04-01 | E-GEOD-72590 | biostudies-arrayexpress
TranscriptomicsKeratinocyte and fibroblast gene expression in skin and keloid scar tissue
Keloids are scars that extend beyond original wounds and are resistant to treatment. In order to improve understanding of the molecular basis of keloid scarring, we have assessed the genomic profiles of keloid fibroblasts and keratinocytes. Skin and scar tissues were obtained for isolation of prima...
ORGANISM(S): Homo sapiens 
2013-05-28 | E-GEOD-44270 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of peripheral blood mononuclear cells from HIV and HCV coinfected patients before and after 24 weeks of combined antiretroviral therapy.
We aim to characterize HIV and HCV coinfected patient response to combined antiretroviral therapy through genome-wide expression profiling of patients' periperhal blood mononuclear cells before and after treatment initiation (baseline and 24 weeks). Individuals with frank cirrhosis were excluded fr...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-56619 | biostudies-arrayexpress
TranscriptomicsRNA-seq expression analysis to determine expression profile similarities between fibroblasts, induced endothelial cells from fibroblasts, and human dermal microvascular endothelial cells
The goal of this study was to determine the similarity between human dermal microvascular endothelial cells, induced endothelial cells from fibroblasts, and fibroblasts through RNA-seq expression analysis. RNA samples from independently induced cultures, plus fibroblast and human dermal microvascul...
ORGANISM(S): Homo sapiens 
2013-04-14 | E-GEOD-45176 | biostudies-arrayexpress
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