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TranscriptomicsFetal mesenchymal stromal cells differentiating towards chondrocytes acquire a gene expression profile resembling human growth plate cartilage.
We used human fetal bone marrow-derived mesenchymal stromal cells (hfMSCs) differentiating towards chondrocytes as an alternative model for the human growth plate (GP). Our aims were to study gene expression patterns associated with chondrogenic differentiation to assess whether chondrocytes derived...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-40942 | biostudies-arrayexpress
TranscriptomicsInvolvement of ERK, Wnt and BMP2 signaling in human articular chondrocyte dedifferentiation in monolayer culture
Objective: When primary chondrocytes are cultured in monolayer, they undergo dedifferentiation during which they lose their phenotype and their capacity to form cartilage. Dedifferentiation is an obstacle for cell therapy for cartilage degeneration. In this study, we aimed to systemically evaluate ...
ORGANISM(S): Homo sapiens 
2012-11-14 | E-GEOD-42235 | biostudies-arrayexpress
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