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GenomicsGenetic analysis of Hirschsprung disease

Hirschsprung disease (HSCR) is a birth defect resulting from the absence of nerve (ganglion) cells in the gastrointestinal tract. Hirschsprung disease has a population incidence of 1/5,000 live births and most often occurs as an isolated condition. However, approximately 30% of HSCR cases are ass...

phs000497.v1.p1 | EGA
TranscriptomicsEarly life stress in fathers impairs synaptic plasticity in the offspring - brain collected after acute swim stress
We show that traumatic stress experienced by males in early postnatal life impairs memory in their offspring, blocks long-term potentiation (LTP) and favors long-term depression (LTD). These effects are accompanied by suppression of key molecular pathways involved in neuronal plasticity both at rest...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-47847 | biostudies-arrayexpress
TranscriptomicsEarly life stress in fathers impairs synaptic plasticity in the offspring - brain collected at rest
We show that traumatic stress experienced by males in early postnatal life impairs memory in their offspring, blocks long-term potentiation (LTP) and favors long-term depression (LTD). These effects are accompanied by suppression of key molecular pathways involved in neuronal plasticity both at rest...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-47846 | biostudies-arrayexpress
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