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TranscriptomicsmiRNA profiling of human acute myeloid leukaemia Kasumi-1 cell line CD34+38- compartment.
The t(8;21) Acute Myeloid Leukaemia (AML) Kasumi-1cell line with N822K KIT mutation, is a model system for leukemogenesis. As AML initiating cells reside in the CD34+CD38- fraction, we addressed the refined cytogenomic characterization and miRNA expression of Kasumi-1 cell line and its FACS-sorted...
ORGANISM(S): Homo sapiens 
2010-02-19 | E-TABM-909 | biostudies-arrayexpress
TranscriptomicsExpression data from a reversible dasatinib-resistant state in long-term dasatinib-treated c-KIT-mutated Kasumi-1 cell line
Long-term treatment of Kasumi-1 cells at clinically attained doses of dasatinib led to decreased drug-sensitivity by means of IC50 values (relative to treatment-naive cells). Changes were paralled by profound alterations in c-KIT expression and cell signaling signatures. Upon brief discontinuation o...
ORGANISM(S): Homo sapiens 
2013-11-27 | E-GEOD-39073 | biostudies-arrayexpress
GenomicsGATA-2 occupancy in Kasumi-3 cell line
GATA-2 is a master regulator of hematopoiesis which controls expression of multiple genes and is implicated in acute myeloid leukemia (AML). However, the molecular mechanism how GATA-2 deregulation causes leukemogenesis is still unclear. In this study, GATA-2 ChIP-squ analysis was conducted in Kasum...
ORGANISM(S): Homo sapiens 
2016-08-05 | E-GEOD-84782 | biostudies-arrayexpress
TranscriptomicsRNA-seq of shControl and shRUNX1-ETO Kasumi-1 cells
RUNX1-ETO knockdown was performed in Kasumi-1 cells and transcriptomic analyses by RNA-sequencing were performed at two different time points (day2 and day9). Control cells (Kasumi-1 shControl) were also analysed at day2 and day9. All samples were analysed in triplicates.
ORGANISM(S): Homo sapiens 
2022-02-01 | E-MTAB-9016 | biostudies-arrayexpress
TranscriptomicsPro-seq of shControl and shRUNX1-ETO Kasumi-1 cells
RUNX1-ETO knockdown was performed in Kasumi-1 cells and Pro-seq analyses were performed. Control cells (Kasumi-1 shControl) were also analysed and all samples were analysed in duplicates.
ORGANISM(S): Homo sapiens 
2022-02-01 | E-MTAB-9019 | biostudies-arrayexpress
TranscriptomicsHuman KASUMI-1 cells: Control vs Radotinib (RD) 5uM
Transcriptional profiling of KASUMI-1 cells comparing between control (DMSO-treated) and radotinib treated Kasumi-1 cells at 48hr one-condition experiment, Control vs RD 5 uM. Biological replicates: 1.
ORGANISM(S): Homo sapiens 
2015-09-11 | E-GEOD-72926 | biostudies-arrayexpress
TranscriptomicsExpression analysis of Kasumi-1 cells treated with or without FTY720
The clinical outcomes of M2 subtype Acute Myeloid Leukemia (AML-M2) with t(8;21) are poor. Here we report that FTY720 (Fingolimod), a sphingosine analogue and an FDA approved drug for treatment of multiple sclerosis, showed great antitumorigenic activity against Kasumi-1 cell line, xenograft mouse m...
ORGANISM(S): Homo sapiens 
2014-04-30 | E-GEOD-55772 | biostudies-arrayexpress
GenomicsGenome-wide map of JMJD1C binding in Kasumi-1 cells [ChIP-seq]
The AML1-ETO fusion protein, a transcription factor generated by the t(8;21) translocation in acute myeloid leukaemia (AML), dictates a leukemic program by increasing self-renewal and inhibiting differentiation. Here we demonstrate that the histone demethylase JMJD1C functions as a co-activator for...
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-63484 | biostudies-arrayexpress
TranscriptomicsRNAi profiling of human Kasumi-1 AML1-ETO knockdown samples
Kasumi-1 AML cells that were transfected in triplicate with AML1-ETO or luciferase siRNA constructs by either Amaxa nucleofection or Biorad siLentFect and incubated for 96 hours. Microarrays used to discover an AML1-ETO signature for a GE-HTS screen to identify AML1-ETO modulators. Experiment Overal...
ORGANISM(S): Homo sapiens 
2009-05-11 | E-GEOD-15646 | biostudies-arrayexpress
TranscriptomicsTranscription profiling and RNAi of human Kasumi-1 AML cell line and U937 cell lines - AML1-ETO induction and knockdown
This SuperSeries is composed of the following subset Series:; GSE15646: Kasumi-1 AML1-ETO knockdown samples; GSE15647: U937 AML1-ETO inducible samples Experiment Overall Design: Refer to individual Series
ORGANISM(S): Homo sapiens 
2009-05-08 | E-GEOD-15648 | biostudies-arrayexpress
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