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TranscriptomicsEffects of KAT2B and WDR5 depletion on hepatocyte gene expression
During fasting, increases in circulating pancreatic glucagon maintain glucose balance by up-regulating hepatic gluconeogenesis. Triggering of the cAMP pathway stimulates the gluconeogenic program through the phosphorylation of CREB and via the de-phosphorylation of the CREB coactivator CRTC2. Hormon...
ORGANISM(S): Mus musculus 
2014-04-21 | E-GEOD-47179 | biostudies-arrayexpress
ProteomicsCRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neurodegeneration
Accumulation of aggregated and misfolded proteins, leading to endoplasmic reticulum stress and activation of the unfolded protein response, is a hallmark of several neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. Genetic screens are powerful tools that are proving invalua...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD038395 | Pride
Cortical neurons Kat2b L-moses Endoplasmic reticulum (er) stress Acetylome 
ProteomicsDependency of NELF-E-KAT2B epigenetic axis in breast cancer carcinogenesis
Cancer cells undergo transcriptional reprogramming to drive tumor progression and metastasis. Here, we identified the transcriptional complex, NELF (Negative elongation factor), as an important regulator of this process. Using cancer cell lines and patient-derived tumor organoids, we demonstrated th...
ORGANISM(S): Homo Sapiens (human) 
2023-01-28 | PXD031304 | JPOST Repository
GenomicsTranscriptomic changes in primary intestinal epithelium cells with Kat2a/Kat2b DKO.
Transcriptomic changes in primary intestinal epithelium cells with Kat2a/Kat2b DKO.
PRJNA987626 | ENA
GenomicsEnrichment of dsRNA in primary intestinal epithelium cells with Kat2a/Kat2b DKO.
Enrichment of dsRNA in primary intestinal epithelium cells with Kat2a/Kat2b DKO.
PRJNA987638 | ENA
GenomicsDependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis
Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis
PRJNA802117 | ENA
GenomicsCHIP-seq KAT2B in mouse isolated islet
The Endoplasmic Reticulum (ER) unfolded protein response (UPRer) pathway plays an important role for pancreatic β cells to adapt their cellular responses to environmental cues and metabolic stress. Although altered UPRer gene expression appears in rodent and human type 2 diabetic (T2D) islets, the u...
ORGANISM(S): Mus musculus 
2016-05-03 | GSE78860 | GEO
TranscriptomicsEffects of KAT2B and WDR5 depletion on hepatocyte gene expression
During fasting, increases in circulating pancreatic glucagon maintain glucose balance by up-regulating hepatic gluconeogenesis. Triggering of the cAMP pathway stimulates the gluconeogenic program through the phosphorylation of CREB and via the de-phosphorylation of the CREB coactivator CRTC2. Hormon...
ORGANISM(S): Mus musculus 
2014-04-21 | GSE47179 | GEO
GenomicsDivergent Functions of Histone Acetyltransferase Paralogs KAT2A and KAT2B in Keratinocyte Stemness and Differentiation
Divergent Functions of Histone Acetyltransferase Paralogs KAT2A and KAT2B in Keratinocyte Stemness and Differentiation
PRJNA889419 | ENA
GenomicsKAT2B-Mediated Epigenetic Suppression of RAD51C Enhances Olaparib Sensitivity in Colorectal Cancer
KAT2B-Mediated Epigenetic Suppression of RAD51C Enhances Olaparib Sensitivity in Colorectal Cancer
PRJNA1113624 | ENA
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