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TranscriptomicsGenome-wide gene expression profiles of clear cell renal cell carcinoma; Identification of molecular targets for treatment of renal cell carcinoma
In order to clarify the molecular mechanism involved in renal carcinogenesis, and identify molecular targets for diagnosis and treatment, we analyzed genome-wide gene expression profiles of 15 surgical specimens of clear cell renal cell carcinoma (RCC), compared to normal renal cortex, using a combi...
ORGANISM(S): Homo sapiens 
2012-07-15 | E-GEOD-39364 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of triple negative breast cancer, normal ductal cells, and normal tissues
To identify novel molecular targets for triple negative breast cancer (TNBC), we have employed whole genome microarray expression profiling. We purified 30 surgically resected breast cancer tissue diagnosed triple negative by means of immunohistochemical staining and 13 normal mammary ductal cells...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-38959 | biostudies-arrayexpress
TranscriptomicsGenome-wide gene expression profiling analysis of bone metastases of human non-small cell lung cancer (NSCLC) in mice
Using a multiorgan metastasis model of human NSCLC cells (ACC-LC319/bone2) in NK cell-depleted SCID mice, we attempted to identify genes involved in the organ-selective nature of lung cancer-metastasis process, especially bone metastasis. Genome-wide gene expression profile of 15 metastatic lesions ...
ORGANISM(S): Homo sapiens 
2012-02-21 | E-GEOD-29391 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of 5 cancer cell lines
Gene expression profiles of 5 cancer cell lines, including lung cancer (SBC-5 (duplicate samples), ACC-LC319/bone2, NCI-H1048); and breast cancer (ZR75.1, HCC1397) were analyzed. Cells were cultured following the guidelines published somewhere, and at confluent ~ 80% cells were extracted RNA for mic...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-40559 | biostudies-arrayexpress
TranscriptomicsInvolvement of transcription factor early growth response 4 (EGR4) in lung cancer bone metastasis
EGR4 (early growth response 4), a transcription factor, was previously shown to be up-regulated in lung cancer bone metastasis, compared with its expression in metastasis in other organs, using a multiorgan metastasis model of human small-cell lung cancer cells (SBC-5) in NK cell-depleted SCID mice ...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-40558 | biostudies-arrayexpress
ProteomicsTMT10plex_cTEC_mTEC_beta5tKO-cTEC
TEC cells (K5D1 cTECs in quadruplicate, K5D1 mTECs in triplicate, and K5D1-β5tKO cTECs in triplicate) were lysed in 6 M guanidine-HCl containing 100 mM Tris-HCl, pH 8.0, and 2 mM DTT. The clarified lysates were reduced in 5 mM DTT and alkylated in 27.5 mM iodoacetamide. Proteins were purified by met...
ORGANISM(S): Mus Musculus (mouse) 
2019-10-08 | PXD013132 | JPOST Repository
ProteomicsLFQ_K5D1-cTEC_K5D1-beta5tKO-cTEC
Cortical TECs from K5D1 and K5D1-β5tKO mice were lysed, reduced, alkylated, and subjected to methanol/chloroform precipitation. Proteins were digested with trypsin/Lys-C mix. The digests were desalted using GL-Tip SDB, and the eluates were evaporated in a SpeedVac concentrator and dissolved in 0.1% ...
ORGANISM(S): Mus Musculus (mouse) 
2019-10-08 | PXD013133 | JPOST Repository
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