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TranscriptomicsComparison of gene expression profiles among Nrf1 liver-specific conditional knockout, Nrf2 knockout and Keap1 knockdown mice.
To identify Nrf1-dependent and Nrf2-dependent genes in the liver, we examined the gene expression profiles of Nrf1 Alb-CKO, Nrf2 knockout and Keap1 knockdown mouse livers by microarray analyses. Total RNAs from Nrf1dN/-::Alb-Cre, Nrf1dN/+, Nrf2-/-, Nrf2+/+, Keap1KD/- and Keap1KD/+ mouse livers were ...
ORGANISM(S): Mus musculus 
2012-05-17 | E-GEOD-35124 | biostudies-arrayexpress
TranscriptomicsExpression data in Hepa1c1c7 cells treated with Nrf2 activator, diethyl maleate (DEM)
To examine the gene expression profile of Hepa1c1c7 cells in response to DEM, we performed microarray analysis. Two independent RNA samples from Hepa1c1c7 cells (a mouse hepatoma cell line) treated with 100-µM DEM or DMSO for 6 hours were used for the microarray analysis.
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-38350 | biostudies-arrayexpress
GenomicsNrf2 bindng in C2C12 myotubes
Nrf2 (NF-E2-related-factor-2) contributes to the maintenance of glucose homeostasis in vivo. Nrf2 suppresses blood glucose levels by protecting pancreatic β-cells from oxidative stress and improving peripheral tissue glucose utilization. To elucidate the molecular mechanisms by which Nrf2 contribut...
ORGANISM(S): Mus musculus 
2016-04-06 | E-GEOD-78780 | biostudies-arrayexpress
TranscriptomicsExpression profile of cortices, hippocampi and brainstems of Nrf2 knockout mice under unstressed conditions
Microarray analysis of cortices, hippocampi and brainstems of Nrf2 knockout mice, Three independent RNAs from cortices, hippocampi and brainstems of Nrf2 knockout and wild-type control mice were used for the microarray analyses.
ORGANISM(S): Mus musculus 
2013-08-05 | E-GEOD-47587 | biostudies-arrayexpress
GenomicsComparison of expression profiles of WT and Nrf2AY/AY mutant macrophages under electrophilic stress agent [ChIP-Seq]
Nrf2(A502Y) mutant macrophages Nrf2(AY/AY) macrophages were more susceptible to toxicity of xenobiotics. To confirm preferences of binding sequences of Nrf2 and Nrf2A502Y in vivo, we performed ChIP-Seq analyses using an anti-Nrf2 antibody on the DEM-treated peritoneal macrophages derived from Nrf2+/...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-75175 | biostudies-arrayexpress
ProteomicsQuantitative plasma proteome of mild cognitive impairment
Multiple Affinity Removal Spin Cartridge Human 14 kit (Agilent) was used to remove 14 major proteins from plasma. Samples were denatured with an equivalent volume of trifluoroethanol and reduced with dithiothreitol. Free cysteine residues were alkylated with iodoacetamide. Samples were incubated wi...
ORGANISM(S): Homo Sapiens (human) 
2022-05-11 | PXD025945 | JPOST Repository
ProteomicsPlasma proteome of mild cognitive impairment
Multiple Affinity Removal Spin Cartridge Human 14 kit (Agilent) was used to remove 14 major proteins from plasma. Samples were denatured with an equivalent volume of trifluoroethanol and reduced with dithiothreitol. Free cysteine residues were alkylated with iodoacetamide. Samples were incubated wi...
ORGANISM(S): Homo Sapiens (human) 
2022-05-11 | PXD025937 | JPOST Repository
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