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MetabolomicsDeep longitudinal multi-omics analysis of Bordetella pertussis cultivated in bioreactors highlights medium starvations and transitory metabolisms, associated to vaccine antigen biosynthesis variations and global virulence regulation

Bordetella pertussis is the bacterial causative agent of whooping cough, a serious respiratory illness. An extensive knowledge on its virulence regulation and metabolism is a key factor to ensure pertussis vaccine manufacturing process robustness. The aim of this study was to refine our ...

2023-02-21 | MTBLS5762 | MetaboLights
MetabolomicsConnecting structure and function from organisms to molecules in small-animal symbioses through chemo-histo-tomography
Our understanding of metabolic interactions between small symbiotic animals and bacteria or parasitic eukaryotes that reside within their bodies is extremely limited. This gap in knowledge originates from a methodological challenge, namely to connect histological changes in host tissues induced by b...
2021-07-06 | MTBLS2639 | MetaboLights
UnknownFive-Year Outcome of Operative and Nonoperative Management of Meniscal Tear in Persons Older Than Forty-Five Years.
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S-EPMC6994332 | biostudies-literature
UnknownAssociation Between Baseline Meniscal Symptoms and Outcomes of Operative and Nonoperative Treatment of Meniscal Tear in Patients With Osteoarthritis.
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S-EPMC8408275 | biostudies-literature
UnknownMAPT haplotype-associated transcriptomic changes in progressive supranuclear palsy.
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S-EPMC11330133 | biostudies-literature
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S-EPMC7020554 | biostudies-literature
UnknownAn international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients.
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S-EPMC9534549 | biostudies-literature
UnknownCelebrating neuropathology's contributions to Alzheimer's Disease Research Centers.
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S-EPMC12519528 | biostudies-literature
UnknownTen months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort.
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S-EPMC8791638 | biostudies-literature
UnknownGlobal COVID-19 lockdown highlights humans as both threats and custodians of the environment.
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S-EPMC8135229 | biostudies-literature
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