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TranscriptomicsshRNA profiling of human Ewings sarcoma samples to produce a molecular function map of Ewinga??s Sarcoma
EWS-FLI1 is a chimeric ETS transcription factor that is, due to a chromosomal rearrangement, specifically expressed in Ewing’s sarcoma family tumors (ESFT) and is thought to be the initiating event in the development of the disease. Previous genomic profiling experiments have identified a number o...
ORGANISM(S): Homo sapiens 
2009-05-11 | E-GEOD-14543 | biostudies-arrayexpress
TranscriptomicsNotch is active in Langerhans Cell Histiocytosis and confers pathognomonic features on dendritic cells.
Langerhans cell histiocytosis (LCH) is a disease characterized by the accumulation of eponymous CD1a+ Langerin+ Langerhans-cell (LC)-like dendritic cells (DC) of largely unknown origin. Here we have performed comparative transcriptome analysis of highly purified CD207+/CD1a+ Langerhans cell histiocy...
ORGANISM(S): Homo sapiens 
2012-10-24 | E-GEOD-35340 | biostudies-arrayexpress
TranscriptomicsVariability in functional p53 reactivation by Prima-1Met/APR-246 in Ewing sarcoma
Though p53 mutations are rare in Ewing sarcoma, there is a strong indication that p53-mutant tumors form a particularly bad prognosis group. As such, novel treatment strategies are warranted that would specifically target and eradicate tumor cells containing mutant-p53 in this subset of ES patients....
ORGANISM(S): Homo sapiens 
2013-11-12 | E-GEOD-49967 | biostudies-arrayexpress
TranscriptomicsHypoxia modulates EWS-FLI1 transcriptional signature and enhances malignant properties of Ewing’s tumor cells in vitro
Hypoxia is an important condition in the tumor cell microenvironment and approximately 1-1.5% of the genome is transcriptionally responsive to hypoxia with hypoxia-inducible factor-1 (HIF-1) as a major mediator of transcriptional activation. Tumor hypoxia is associated with a more aggressive phenoty...
ORGANISM(S): Homo sapiens 
2010-02-05 | E-GEOD-19197 | biostudies-arrayexpress
TranscriptomicsRe-activation of EWS-FLI1 suppressed FOXO1 expression as a novel therapeutic strategy for Ewing´s sarcoma
Transient transfection of a Ewing's Sarcoma cell line expressing type I EWS-FLI1 fusion and doxycycline-inducible short hairpin RNA against EWS-FLI1 (A673sh) In total, 7 samples were analysed: empty vector control and two nuclear directed AKT- and CDK2- phosphorylation resistant FOXO1 versions as we...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-37409 | biostudies-arrayexpress
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