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MetabolomicsER stress inhibits liver fatty acid oxidation while unmitigated stress leads to anorexia-induced lipolysis and both liver and kidney steatosis
The unfolded protein response (UPR), induced by endoplasmic reticulum (ER) stress, regulates the expression of factors that restore protein folding homeostasis. However, in the liver and kidney, ER stress also leads to lipid accumulation, accompanied at least in the liver by transcriptional suppress...
2017-06-23 | MTBLS472 | MetaboLights
TranscriptomicsAnalysis of gene expression changes induced in wild-type or Atf6a-/- mice by treatment with tunicamycin for 8h
Protein misfolding stress in the endoplasmic reticulum (ER) leads to dysregulation of lipid metabolism in the liver, and ER stress is associated with human diseases that are accompanied by hepatic lipid accumulation, including obesity, alcoholism, and viral hepatitis; yet the pathways leading from E...
ORGANISM(S): Mus musculus 
2013-09-04 | E-GEOD-48932 | biostudies-arrayexpress
TranscriptomicsAnalysis of gene expression changes induced in wild-type or Atf6a-/- mice by treatment with tunicamycin for 34h
Protein misfolding stress in the endoplasmic reticulum (ER) leads to dysregulation of lipid metabolism in the liver, and ER stress is associated with human diseases that are accompanied by hepatic lipid accumulation, including obesity, alcoholism, and viral hepatitis; yet the pathways leading from E...
ORGANISM(S): Mus musculus 
2013-09-04 | E-GEOD-48935 | biostudies-arrayexpress
TranscriptomicsNovel Bioinformatics Method for Identification of Genome-Wide Non-Canonical Spliced Regions using RNA-Seq Data
We developed a bioinformatics approach called the Read-Split-Walk (RSW) pipeline, and evaluated it using two Ire1? heterozygous and two Ire1?-null samples. The 26nt non-canonical splice site in Xbp1 was detected as the top hit by our RSW pipeline in heterozygous samples but not in the negative contr...
ORGANISM(S): Mus musculus 
2014-07-29 | E-GEOD-54631 | biostudies-arrayexpress
UnknownOverall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer.
Not available
S-EPMC10207856 | biostudies-literature
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