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TranscriptomicsExpression data from neutrophils from wild-type and Jdp2-/- mice
Jdp2 is a member of the AP-1 family and suppresses histone acetyltransferase activity. We used microarrays to examine the gene expression pattern of neutrophil form Jdp2-/- mice. Bone marrow CD11b+Ly6Clo Ly6G+ neutrophils form wild-type and Jdp2-/-mice were sorted by FACS, followed by RNA extraction...
ORGANISM(S): Mus musculus 
2012-11-30 | E-GEOD-42063 | biostudies-arrayexpress
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAMPT targeted therapy)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7252 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAD targeted time-course)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7253 | MetaboLights
ProteomicsTMTpro-16plex analysis of worm embryos with unc-32 RNAi
An rrf-1(pk1417) mutant strain was used to knockdown unc-32 gene function specifically in the germline, in which somatic RNAi, but not germline RNAi, was significantly repressed. Gravid adult hermaphrodites were collected in M9 buffer and bleached to obtain hard-shelled embryos. The embryos were was...
ORGANISM(S): Caenorhabditis Elegans 
2026-04-09 | PXD065081 | JPOST Repository
ProteomicsDIA of GFP-Trap IP from worms expressing ROOM1/2-GFP
Worms containing the transgene room-1::FLAG::GFP or room-2::FLAG::GFP were used for the Co-IP MS experiments. Approximately 25,000 gravid adult hermaphrodites were collected and homogenized in HBS buffer (20 mM HEPES-NaOH pH7.5, 150 mM NaCl, 1 mM MgCl2, and 1 mM EDTA with Complete Ultra Tablet Mini,...
ORGANISM(S): Caenorhabditis Elegans 
2026-04-09 | PXD065091 | JPOST Repository
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