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TranscriptomicsAlternative splicing in human temporal cortex
We analysed changes in transcript levels and alternative splicing in the temporal cortex of individuals of different ages that were cognitively normal, affected by frontotemporal lobar degeneration (FTLD), or affected by Alzheimer's disease (AD). Our experiment's purpose is to provide new insights i...
ORGANISM(S): Homo sapiens 
2012-04-27 | E-MTAB-656 | biostudies-arrayexpress
TranscriptomicsRNAi profiling by array of human HeLa cells with hnRNP C siRNA knockdown using a splice-junction microarray to detect changes in alternative splicing.
poly(A)+ RNA samples from hnRNP C siRNA knockdown and control HeLa cells were compared on a splice-junction microarray to detect changes in alternative splicing. Using the ASPIRE3 algorithm, we detected changes in splicing at 1,340 alternative exons. We observed a similar incidence of increased or d...
ORGANISM(S): Homo sapiens 
2010-10-01 | E-MTAB-367 | biostudies-arrayexpress
TranscriptomicsCLIP-Seq of H. sapiens HeLa cells to investigate transcriptome-wide mapping of PTB / hnRNP I
PTB iCLIP-seq in HeLa cells
ORGANISM(S): Homo sapiens 
2014-12-01 | E-MTAB-3108 | biostudies-arrayexpress
Transcriptomicsmonitoring splicing changes in TIA1/TIAL1 double knockdown vs control HeLa cells
Not available
ORGANISM(S): Homo sapiens 
2010-10-26 | E-MTAB-526 | biostudies-arrayexpress
TranscriptomicsCLIP-Seq of H. sapiens HeLa cells to investigate transcriptome-wide mapping of Matrin3
Matr3 iCLIP with 4thio-uridine labelling in HeLa cells
ORGANISM(S): Homo sapiens 
2014-12-01 | E-MTAB-3107 | biostudies-arrayexpress
TranscriptomicsHif1-alpha dependent splice factor expression and alternative splicing in neonatal mouse cardiomyocytes (NMC)
Neonatal mouse cardiomyocytes (NMC) were cultured in normoxia (21% O2) or hypoxia (3% O2) with and without a lentiviral shRNA-mediated knockdown of Hif1-alpha. Total RNA was extracted from NMC using RNeasy kit, cDNA was synthesized using GeneChip WT cDNA Synthesis and Amplification kit (Affymetrix 9...
ORGANISM(S): Mus musculus 
2015-06-02 | E-MTAB-2652 | biostudies-arrayexpress
TranscriptomicsCLIP-Seq of human brain and neuroblastoma sample to characterisethe RNA targets and position-dependent splicing regulation by TDP-43
iCLIP (UV-crosslinking and immunoprecipitation followed by sequencing ) analysis of TDP-43 RNA binding sites
ORGANISM(S): Homo sapiens 
2011-07-21 | E-MTAB-530 | biostudies-arrayexpress
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