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TranscriptomicsMicroarray analysis of WT and L-Myc-deficient DC subsets
Analysis of L-Myc-dependent genes in pDCs and classical DC subsets with and without stimulation. Splenocytes were harvested from C57BL/6 wild-type (WT) or 10 generation C57BL/6 backcrossed Mycl1-gfp/gfp (LmycKO) mice and DC subsets sorted to >95% purity on the FACSAriaII.
ORGANISM(S): Mus musculus 
2013-12-14 | E-GEOD-53312 | biostudies-arrayexpress
TranscriptomicsBcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo
Bcl11a is a transcription factor known to regulate lymphoid and erythroid development. Recent bioinformatic analysis of global gene expression patterns has suggested a role for Bcl11a in the development of dendritic cell (DC) lineages. We tested this hypothesis by analyzing the development of DC and...
ORGANISM(S): Mus musculus 
2013-05-06 | E-GEOD-46270 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse hypomorphic for ATG16L1 (implicated in Crohns disease) protein expression reveals a key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
Susceptibility to Crohn's disease, a complex inflammatory disease involving the small intestine, is controlled by over 30 loci. One Crohn's disease risk allele is in ATG16L1, a gene homologous to the essential yeast autophagy gene ATG16 (ref. 2). It is not known how ATG16L1 or autophagy contributes ...
ORGANISM(S): Mus musculus 
2008-11-15 | E-GEOD-13512 | biostudies-arrayexpress
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