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MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
UnknownNegative cooperativity underlies dynamic assembly of the Par complex regulators Cdc42 and Par-3.
Not available
S-EPMC9793311 | biostudies-literature
UnknownEnergetic determinants of animal cell polarity regulator Par-3 interaction with the Par complex.
Not available
S-EPMC9352551 | biostudies-literature
UnknownThe Drosophila neuroblast polarity cycle at a glance.
Not available
S-EPMC10984279 | biostudies-literature
UnknownDevelopmental Models of Depression, Externalizing Problems, and Self-regulatory Processes: Integrated Data Analysis Across Four Longitudinal Studies of Youth.
Not available
S-EPMC10821791 | biostudies-literature
TranscriptomicsExpression data comparing the effect of IKK2 KO on a KRAS mouse model
Given that the NF-κB pathway plays an important role in tumor development and that IKK2 is the seminal kinase responsible for NF-κB pathway activation, we were particularly interested in exploring the therapeutic potential of IKK2 inhibition in non-small cell lung cancers. We crossed IKK2fl/fl and K...
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-30049 | biostudies-arrayexpress
TranscriptomicsExpression data of transduced mouse glioblastomas
Transgenic GFAP-, NES-, and SYN- CRE mice were injected with a lenti-viral construct containing a floxed RFP directly upstream of a cassette containing si-p53, GFP, and mutant HRAS. Tumors arising from the various CRE tissue specific promoters and differing injections sites were compared to normal h...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-35917 | biostudies-arrayexpress
UnknownReactions to the U.S. Preventive Services Task Force guidelines for the management of adolescent obesity: A multi-informant qualitative approach.
Not available
S-EPMC10680043 | biostudies-literature
UnknownCopy number variation in the complement factor H-related genes and age-related macular degeneration.
Not available
S-EPMC3156785 | biostudies-literature
TranscriptomicsConsequences of GATA1 expression in Gata1- G1ME Murine Megakaryocyte/Erythrocyte Progenitor Cell Line
G1ME cells are GATA1-deficient murine bipotential megakaryocyte/erythrocyte progenitor cells derived from Gata1-negative murine ES cells. In order to assess the impact of GATA1 on gene regulation and cell differentiation, an expression construct was used to transiently produce high levels of GATA1....
ORGANISM(S): Mus musculus 
2009-06-10 | E-GEOD-14980 | biostudies-arrayexpress
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