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GenomicsWhole-genome nucleosome mapping in meiotic diploid S. cerevisiae
We determined nucleosome positions throughout the genome in diploid S. cerevisiae undergoing early stages of synchronous meiosis. This study sought to assess if systematic reorganization of nucleosomes occurs during meiotic prophase at or near sites of DNA double strand break formation. Six samples ...
ORGANISM(S): Saccharomyces cerevisiae 
2011-03-07 | E-GEOD-26452 | biostudies-arrayexpress
GenomicsBas1 and Ino4 ChIP-seq
Meiotic recombination is initiated by developmentally programmed DNA double-strand breaks (DSBs). In S. cerevisiae, the vast majority of DSBs occur in the nucleosome-depleted regions at gene promoters, where transcription factors (TFs) bind. It has been proposed that TF binding can stimulate DSB for...
ORGANISM(S): Saccharomyces cerevisiae 
2015-08-21 | E-GEOD-67912 | biostudies-arrayexpress
ProteomicsANKRD31 protein interactions
Sex chromosomes in males of most mammalian species share only a small homologous segment, the pseudoautosomal region (PAR), wherein double-strand break (DSB) formation must occur for correct meiotic segregation. We find that multiple DSB-promoting factors hyperaccumulate in the PAR, including the an...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-19 | PXD017191 | Pride
Mouse 
TranscriptomicsSpo11-oligo mapping in S. cerevisiae Ctf19/CCAN kinetochore sub-complex mutant mcm21
During meiosis, crossover recombination is essential to link homologous chromosomes and drive faithful chromosome segregation. Crossover recombination is non-random across the genome, and centromere-proximal crossovers are associated with an increased risk of aneuploidy, including Trisomy 21 in huma...
ORGANISM(S): Saccharomyces cerevisiae 
2015-12-15 | E-GEOD-72683 | biostudies-arrayexpress
GenomicsSpo11-oligo mapping in bas1 and ino4 mutants
Meiotic recombination is initiated by developmentally programmed DNA double-strand breaks (DSBs). In S. cerevisiae, the vast majority of DSBs occur in the nucleosome-depleted regions at gene promoters, where transcription factors (TFs) bind. It has been proposed that TF binding can stimulate DSB for...
ORGANISM(S): Saccharomyces cerevisiae 
2015-08-21 | E-GEOD-67910 | biostudies-arrayexpress
GenomicsHistone 3 lysine 4 trimethylation (H3K4me3) ChIP in bas1 and ino4 mutants
Meiotic recombination is initiated by developmentally programmed DNA double-strand breaks (DSBs). In S. cerevisiae, the vast majority of DSBs occur in the nucleosome-depleted regions at gene promoters, where transcription factors (TFs) bind. It has been proposed that TF binding can stimulate DSB for...
ORGANISM(S): Saccharomyces cerevisiae 
2015-08-21 | E-GEOD-67907 | biostudies-arrayexpress
TranscriptomicsSpo11-oligo mapping in zip3 mutants
Meiotic recombination promotes genetic diversification as well as pairing and segregation of homologous chromosomes, but the double-strand breaks (DSBs) that initiate recombination are dangerous lesions that can cause mutation or meiotic failure. How cells control DSBs to balance between beneficial ...
ORGANISM(S): Saccharomyces cerevisiae 
2014-04-23 | E-GEOD-48299 | biostudies-arrayexpress
GenomicsGenome-wide mapping of meiotic double-strand breaks by sequencing Spo11 oligos.
The nonrandom distribution of meiotic recombination shapes patterns of inheritance and genome evolution, but chromosomal features governing this distribution are poorly understood. Formation of the DNA double-strand breaks (DSBs) that initiate recombination results in accumulation of Spo11 protei...
ORGANISM(S): Saccharomyces cerevisiae 
2011-03-07 | E-GEOD-26449 | biostudies-arrayexpress
GenomicsRec114 ChIP-seq
DNA duplication is intimately connected to setting up post-replicative chromosome structures and events, but molecular details of this coordination are not well understood. A striking example occurs during yeast meiosis, where replication locally influences timing of the DNA double-strand breaks (DS...
ORGANISM(S): Saccharomyces cerevisiae 
2014-07-21 | E-GEOD-52970 | biostudies-arrayexpress
TranscriptomicsNumerical and Spatial Patterning of Yeast Meiotic DNA Breaks by Tel1
The Spo11-generated double-strand breaks (DSBs) that initiate meiotic recombination are dangerous lesions that can disrupt genome integrity, so meiotic cells regulate their number, timing, and distribution. Here, we use Spo11-oligonucleotide complexes, a byproduct of DSB formation, to examine the co...
ORGANISM(S): Saccharomyces cerevisiae 
2016-07-22 | E-GEOD-84696 | biostudies-arrayexpress
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