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ProteomicsLarge-Scale Quantitative Cross-Linking and Mass Spectrometry Provides New Insight on Protein Conformational Plasticity within Organelles, Cells, and Tissues
Many proteins can exist in multiple conformational states in vivo to achieve distinct functional roles. These states include alternative conformations, variable PTMs, and association with interacting protein, nucleotide, and ligand partners. Quantitative chemical cross-linking of live cells, organel...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD058430 | Pride
M.musculus qxl-ms 
ProteomicsHeLa Cells Cross-Linked In Vivo versus as a Lysate
HeLa Cells were cross-linked with PIR either in vivo or as a lysate.
ORGANISM(S): Homo sapiens (Human) 
2019-07-12 | PXD013063 | Pride
Pir cross-linker xl-ms 
ProteomicsLarge-Scale Quantitative Cross-Linking and Mass Spectrometry Provides New Insight on Protein Conformational Plasticity within Organelles, Cells, and Tissues
Many proteins can exist in multiple conformational states in vivo to achieve distinct functional roles. These states include alternative conformations, variable PTMs, and association with interacting protein, nucleotide, and ligand partners. Quantitative chemical cross-linking of live cells, organel...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD058437 | Pride
H.sapiens qxl-ms 
ProteomicsLarge-Scale Quantitative Cross-Linking and Mass Spectrometry Provides New Insight on Protein Conformational Plasticity within Organelles, Cells, and Tissues
Many proteins can exist in multiple conformational states in vivo to achieve distinct functional roles. These states include alternative conformations, variable PTMs, and association with interacting protein, nucleotide, and ligand partners. Quantitative chemical cross-linking of live cells, organel...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD058448 | Pride
M.mulsculus qxl-ms 
ProteomicsLarge-Scale Quantitative Cross-Linking and Mass Spectrometry Provides New Insight on Protein Conformational Plasticity within Organelles, Cells, and Tissues
Many proteins can exist in multiple conformational states in vivo to achieve distinct functional roles. These states include alternative conformations, variable PTMs, and association with interacting protein, nucleotide, and ligand partners. Quantitative chemical cross-linking of live cells, organel...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD058435 | Pride
H.sapiens qxl-ms 
ProteomicsLarge-Scale Quantitative Cross-Linking and Mass Spectrometry Provides New Insight on Protein Conformational Plasticity within Organelles, Cells, and Tissues
Many proteins can exist in multiple conformational states in vivo to achieve distinct functional roles. These states include alternative conformations, variable PTMs, and association with interacting protein, nucleotide, and ligand partners. Quantitative chemical cross-linking of live cells, organel...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD058490 | Pride
M.musculus qxl-ms 
ProteomicsQuantitative Analysis of Samples Labeled with Multiplex iqPIR Cross-Linkers
The isobaric quantitative protein interaction reporter (iqPIR) has now been extended to six channels, enabling quantitation of cross-links from six different samples simultaneously. To analyze data for such cross-linkers, the two-channel mode of quantitative analysis was extended to accommodate any...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD025796 | Pride
Quantitative analysis Mass spectrometry Crosslinking Multiplex iqpir 
UnknownBioactivity-driven fungal metabologenomics identifies antiproliferative stemphone analogs and their biosynthetic gene cluster.

Introduction

Fungi biosynthesize chemically diverse secondary metabolites with a wide range of biological activities. Natural product scientists have increasingly turned towards bioinformatics approaches, combining metabolomics and genomics to target secondary metabolites and their biosynthe...
S-EPMC11296971 | biostudies-literature
ProteomicsChemical cross-linking mass spectrometry for systems structural biology in mouse heart tissue.
While modern structural biology technologies have greatly expanded the size and type of protein complexes that can now be studied, the ability to derive large-scale structural information on proteins and complexes as they exist within tissues is practically non-existent. Many protein properties and...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-30 | PXD007673 | Pride
Mass spectrometry Structural biology Mouse Heart Protein-protein interactions Cross-linking 
UnknownThe Gene Ontology: enhancements for 2011.
The Gene Ontology (GO) (http://www.geneontology.org) is a community bioinformatics resource that represents gene product function through the use of structured, controlled vocabularies. The number of GO annotations of gene products has increased due to curation efforts among GO Consortium (GOC) grou...
S-EPMC3245151 | biostudies-literature
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