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MetabolomicsPhospholipid acyl chain diversity controls the tissue-specific assembly of mitochondrial cardiolipins

Cardiolipin (CL) is a phospholipid specific for mitochondrial membranes and crucial for many core tasks of this organelle. Its side chain configurations are tissue-specific, functionally important and generated via post-biosynthetic remodeling. However, this process lacks the necessary specificit...

2020-05-22 | MTBLS1446 | MetaboLights
MetabolomicsMolecular structural diversity of mitochondrial cardiolipins
Current strategies used to quantitatively describe the biological diversity of lipids by mass spectrometry are often limited in assessing the exact structural variability of individual molecular species in detail. A major challenge is represented by the extensive isobaric overlap present among lipid...
2021-01-11 | MTBLS636 | MetaboLights
ProteomicsMicrobial functionality as affected by experimental warming of a temperate mountain forest soil - a metaproteomics survey
Soils are a huge reservoir of organic C, and the efflux of CO2 from soils is one of the largest fluxes in the global C cycle. Out of all natural environments, soils probably contain the greatest microbial biomass and diversity, which classifies them as one of the most challenging habitats for microb...
ORGANISM(S): uncultured soil microorganism 
2022-03-14 | PXD004428 | Pride
Soil microbial diversity Microbial community functionality Soil warming 
TranscriptomicsRNA-Seq of conventional and regulatory CD4+ T cells of healthy human donors
Transcriptional profiles of conventional and regulatory CD4+ T cells were compared in healthy individuals (caucasian males).
ORGANISM(S): Homo sapiens 
2020-03-04 | E-MTAB-8819 | biostudies-arrayexpress
TranscriptomicsRegulatory and effector T cells in Lymphocytic choriomeningitis virus WE infection
In this study, we determined the signature of CD4+Foxp3- effector T cells and CD4+Foxp3+ Treg cells in naive animals and following LCMV WE infection. In addition, transcriptional signatures were determined in CXCR3+ CD4+Foxp3+ Treg cells arising in Th1 settings following LCMV infection.
ORGANISM(S): Mus musculus 
2020-03-11 | E-MTAB-8861 | biostudies-arrayexpress
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