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ProteomicsKetone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding
Time-restricted feeding (TRF) has gained attention as a dietary regimen that promotes metabolic health. This study sought to determine if ketone flux in skeletal and cardiac muscles plays an essential role in conferring the health benefits of an intermittent TRF (iTRF) schedule. Notably, we found th...
ORGANISM(S): Mus Musculus (mouse) 
2024-02-09 | PXD047114 | JPOST Repository
ProteomicsComprehensive respiratory phenomics across multiple models of mitochondrial protein hyperacylation reveals a paradoxically marginal impact on bioenergetics
Acyl CoA metabolites derived from catabolism of carbon fuels can react with lysine residues of mitochondrial proteins, giving rise to a large family of post-translation modifications (PTMs). Mass spectrometry-based detection of thousands of acyl-PTMs scattered throughout the proteome has established...
ORGANISM(S): Mus Musculus (mouse) 
2019-02-07 | PXD011375 | JPOST Repository
TranscriptomicsEffects of 17M-NM-1-ethinylestradiol (EE2) on molecular signaling cascades in mummichog (Fundulus heteroclitus)
The objective of this study was to gain mechanistic insight into how mummichog are able to produce eggs during exposures to high levels of EE2. Mummichog were exposed to 0, 50 or 250 ng/L of EE2 for 14 d. A mummichog microarray was used to identify genomic responses associated with high EE2 exposure...
ORGANISM(S): Fundulus heteroclitus 
2013-07-18 | E-GEOD-48945 | biostudies-arrayexpress
MetabolomicsMetabolomic profiling of Fraxinus excelsior genotypes tolerant or susceptible to ash dieback disease reveals changes in iridoid glycosides
European common ash, Fraxinus excelsior L., is currently threatened by Ash dieback (ADB) caused by the fungus, Hymenoscyphus fraxineus. To detect and identify metabolites that may be products of pathways important in contributing to resistance against H. fraxineus we performed untargeted metabolomic...
2016-11-09 | MTBLS372 | MetaboLights
TranscriptomicsGlobal gene expression in response to SARS mouse adapted variants MA-15, MA-15epsilon, and MA-15-gamma in young and aged mice
Purpose of this experiment was to study the host-transcriptional response to MA-15, MA-15epsilon, and MA-15-gamma in both young and aged mice to further understand the differences between response within each age group, and the age-related differences in response to each virus. Young (8 weeks old) a...
ORGANISM(S): Mus musculus 
2014-06-02 | E-GEOD-36969 | biostudies-arrayexpress
GenomicsPCGP Ph-like ALL
Background: BCR-ABL1-like, or Ph-like acute lymphoblastic leukemia is characterized by a gene expression profile similar to BCR-ABL1 positive ALL, genetic alterations of lymphoid transcription factor genes, and poor outcome. Sequencing of small numbers of Ph-like ALL cases has identified genetic alt...
EGAS00001000654 | EGA
GenomicsPCGP Ph-likeALL RNASeq - samples
DATA FILES FOR SJPhLike-RNASeq
EGAD00001001016 | EGA
GenomicsPCGP Ph-likeALL SNP6 - samples
PCGP Ph-likeALL SNP6
EGAD00010000598 | EGA
GenomicsPCGP Ph-likeALL WES - samples
DATA FILES FOR Ph-likeALL WES
EGAD00001001054 | EGA
GenomicsPCGP Ph-likeALL WGS - samples
WGS DATA FILES FOR SJPhLike
EGAD00001000976 | EGA
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