Sort   by:  
 Page size 
UnknownPLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice
While Epstein-Barr virus (EBV) establishes a life-long latent infection in apparently healthy human immunocompetent hosts, immunodeficient individuals are at particular risk to develop lymphoproliferative B cell malignancies caused by EBV. A key EBV protein is the transcription factor EBV nuclear an...
S-SCDT-EMBOR-2021-53007-T | biostudies-other
GenomicsModulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs epigenetic reprogramming
Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes deregulated by specific combinations of these EBNAs thr...
ORGANISM(S): Homo sapiens 
2013-09-13 | E-GEOD-47629 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human EBV- cell lines BL41K3 and BJABK3 expressing a chimeric EBNA-2 protein treated with estrogen to induce expression of ER/EBNA-2 and downstream genes to identify cellular target genes of EBV nuclear antigen 2
Two cell lines, BL41K3 and BJABK3, were chosen to perform a comprehensive screen for EBNA-2 target genes. Both cell lines are EBV negative B-cell lines and express a chimeric EBNA-2 protein fused to the hormone binding domain of the estrogen receptor (ER/EBNA-2). The cells are propagated in the abse...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4525 | biostudies-arrayexpress
Sort   by:  
 Page size