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ProteomicstRNA hydroxylation is an epitranscriptomic modulator of metabolic states affecting Pseudomonas aeruginosa pathogenicity
Post-transcriptional modification of tRNAs represents an essential layer of translational regulation critical for bacterial adaptation to environmental changes. Increasing evidence links the tRNA epitranscriptome to pivotal roles in the regulation of gene expression and various cellular processes, i...
ORGANISM(S): Pseudomonas aeruginosa (strain UCBPP-PA14) 
2025-08-04 | PXD060249 | Pride
Trna modification Pseudomonas aeruginosa Epitranscriptomics 
ProteomicsDynamic tRNA modification programs align codon usage with growth-phase-specific gene expression in Pseudomonas aeruginosa
Post-transcriptional tRNA modifications dynamically regulate translational capacity, yet whether the tRNA epitranscriptome is temporally coordinated with gene expression programs during bacterial growth remains unknown. Here, we combine time-resolved nanopore tRNA sequencing, LC-MS/MS modification p...
ORGANISM(S): Pseudomonas aeruginosa Bacteria 
2026-10-03 | PXD077153 | Pride
Trna modification Pseudomonas aeruginosa 
ProteomicsMiaA-mediated tRNA modifications couple tryptophan biosynthesis operon attenuation and changes in tRNA abundance to complex phenotypes in Pseudomonas aeruginosa
tRNA-modifying enzymes are emerging as key regulators of bacterial physiology. MiaA, a tRNA isopentenyltransferase, is well studied in model organisms, but its role in the pathogen Pseudomonas aeruginosa remains unclear. Using LC–MS, nanopore sequencing, and transcriptional, translational and proteo...
ORGANISM(S): Pseudomonas aeruginosa PA14 Bacteria 
2026-09-07 | PXD076088 | Pride
Trna-modifying enzymes Pseudomonas aeruginosa 
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