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MetabolomicsN6-methyladenosine modification is not a general trait of positive-sense RNA viral genomes

Despite the nuclear localization of the m6A machinery, the genomes of multiple exclusively-cytoplasmic RNA viruses, such as chikungunya (CHIKV) and dengue (DENV), are reported to be extensively m6A-modified. However, these findings are mostly based on m6A-seq, an antibody-dependent technique with...

2024-01-25 | MTBLS6978 | MetaboLights
ProteomicsProteomics Analysis of the Inferior Colliculus following Acute Hydrogen Sulfide
We used broad-spectrum proteomics to search for key molecules in H2S induced neurotoxicity. Mice were subjected to acute whole body exposure up to 750ppm of H2S at day1 for 40min, followed by 15min daily exposure. Following H2S exposure, inferior colliculi were harvested on day1, day2, and day4 and...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-10-26 | MSV000081650 | MassIVE
TranscriptomicsMolecular Dissection of Pea Shoot Apical Meristem
Knowledge about an organism’s cell and tissue-specific transcriptional repertoire is essential for understanding the gene regulatory circuits that control key developmental events. The shoot apical meristem (SAM) is responsible for development of all the above ground parts of plants. Our underst...
ORGANISM(S): Pisum sativum 
2010-06-20 | E-GEOD-13451 | biostudies-arrayexpress
TranscriptomicsOxidative burden and mitochondrial dysfunction in a mouse model of Rett syndrome
To identify the detailed molecular causes of the mitochondrial dysfunction, oxidative burden and more vulnerable redox balance in Rett mouse hippocampus, we screened for differential gene expression in the hippocampal CA1 subfield of adult male mice. A whole mouse genome microarray was performed to ...
ORGANISM(S): Mus musculus 
2012-08-31 | E-GEOD-32870 | biostudies-arrayexpress
TranscriptomicsProgerin Expression in Endothelial Cells Induces Endothelial Dysfunction
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare, genetic premature aging disorder associated with severe atherosclerosis, often resulting in fatal heart attacks and strokes. Progerin, the mutant protein in HGPS, also is expressed in healthy individuals and may play a role in the development o...
ORGANISM(S): Homo sapiens 
2010-12-02 | E-GEOD-19270 | biostudies-arrayexpress
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