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MetabolomicsSteam-exploded okara ameliorates hepatic lipid metabolism in high-fat diet-induced obese C57BL/6J mice: Evidence from multi-omics characterization

Okara, a byproduct of soybean processing, possesses valuable nutritional and physiological properties. Steam explosion, an efficient physical modification technique, can increase the soluble dietary fiber (SDF) content in okara and potentially amplify its health benefits, such as anti-obesity eff...

2025-10-23 | MTBLS13154 | MetaboLights
TranscriptomicsGenome-wide microRNA expression induced by TNF
We sequenced microRNAs from bone marrow derived macrophages derived from the control (WT) and RBP-J conditional knockout mice (RBP-J KO; Rbpjf/f; LysM Cre). Examination of differential microRNA expression levels induced by TNF as well as regulated by RBP-J in bone marrow derived macrophages.
ORGANISM(S): Mus musculus 
2016-07-22 | E-GEOD-72966 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse lung from C57BL/6J and A/J mice during embryonic development
In this study, time dependent genome wide lung mRNA profiling changes were assessed using C57BL/6J and A/J mice. Through comprehensive bioinformatics and functional genomics analyses, we identified both temporal and strain dependent gene expression patterns, systemically mapped key regulators, biopr...
ORGANISM(S): Mus musculus 
2012-07-30 | E-GEOD-35485 | biostudies-arrayexpress
TranscriptomicsAllelic dilution series series of C57BL6/J:CAST/EiJ RNA using Smart-seq3
Technical control for allelic detection using Smart-seq3. Liver RNA from pure C57BL6/J and CAST/EiJ strains was combined at varying ratios (0:1, 1:7, 1:3, 3:5, 1:1, 5:3, 3:1, 7:1, 1:0) for a total of 200 pg RNA per sample.
ORGANISM(S): Mus musculus 
2022-02-14 | E-MTAB-10709 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of acteylcholine receptor immunization between RIIIS/J and B10.RIII mice
Comparison of acetylcholine receptor immunization between RIIIS/J and B10.RIII mice.
ORGANISM(S): Mus musculus 
2004-03-11 | E-MEXP-86 | biostudies-arrayexpress
MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
TranscriptomicsTranscription profiling of mouse AKR/J and C57Bl/6J strain pancreatic islets from high fat fed
Increased fat intake is associated with obesity and insulin resistance. In some individuals, a failure of pancreatic b-cells to increase insulin production in response to the high demands of obesity leads to diabetes. We sought to determine whether the impaired b- cell adaptation in obesity is assoc...
ORGANISM(S): Mus musculus 
2008-04-07 | E-GEOD-10639 | biostudies-arrayexpress
TranscriptomicsCerebellar oxidative DNA damage and altered DNA methylation in the BTBR T+tf/J mouse model of autism and similarities with human post mortem cerebellum.
The molecular pathogenesis of autism is complex and involves numerous genomic, epigenomic, proteomic, metabolic, and physiological alterations. Elucidating and understanding the molecular processes underlying the pathogenesis of autism is critical for effective clinical management and prevention of...
ORGANISM(S): Mus musculus 
2014-10-23 | E-GEOD-62594 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of femoral diaphysis and primary osteoprogenitor cells cultures from mouse strains with SHIP1 deficiency and controls
Investigation of the SHIP1 (Inpp5d)-dependent and Rag2/Il2rg-dependent transcriptional changes in bone and osteoprogenitor cells cultures from murine strains with SHIP1 deficiency (Inpp5dm1Btlr/ m1Btlr, http://www.informatics.jax.org/allele/key/65037) and controls. Specifically, transcriptomic anal...
ORGANISM(S): Mus musculus 
2024-02-21 | E-MTAB-13164 | biostudies-arrayexpress
TranscriptomicsCell-context dependent Notch target genes
Notch signaling regulates a variety of developmental cell fates decisions in a cell-context dependent manner. Although Notch signaling directly regulates transcription via the RBP-J/CSL DNA binding protein, little is known about the genes in the respective tissues that are directly activated by Notc...
ORGANISM(S): Mus musculus 
2010-07-13 | E-GEOD-15268 | biostudies-arrayexpress
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