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UnknownPhase III, Randomized Study of Dual Human Epidermal Growth Factor Receptor 2 (HER2) Blockade With Lapatinib Plus Trastuzumab in Combination With an Aromatase Inhibitor in Postmenopausal Women With HER2-Positive, Hormone Receptor-Positive Metastatic Breast Cancer: ALTERNATIVE.
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S-EPMC7444639 | biostudies-literature
TranscriptomicsSchladebeck_Whi3_Ploidy
We analyzed and classified Whi3-regulated and ploidy-regulated genes in haploid and diploid strains of the Sigma1278b genetic background under vegetative growth conditions.

For this purpose, we measured transcriptional profiles of two different haploid MATa and one diploid MATa/a yeast strain...
ORGANISM(S): Saccharomyces cerevisiae 
2013-06-19 | E-MEXP-3610 | biostudies-arrayexpress
TranscriptomicsAvian resistance to Campylobacter jejuni colonization is associated with an intestinal immunogene expression signature identified by mRNA sequencing.
RNAseq analysis of caecal tissue from 14 C. jejuni-susceptible and 14 C. jejuni-resistant birds from a single population of infected chickens was conducted in order to identify gene expression associated with resistance to colonization. Significantly higher expression of genes involved in the innate...
ORGANISM(S): Gallus gallus 
2013-02-15 | E-GEOD-44341 | biostudies-arrayexpress
MetabolomicsAssessing the impact of nitrogen supplementation in oats across multiple growth locations and years with targeted phenotyping and high-resolution metabolite profiling approaches
Oats (Avena sativa L.) are a healthy food, being high in dietary fibre (e.g. β-glucans), antioxidants, minerals, and vitamins. Understanding the effect of variety and crop management on nutritional quality is important. The response of four oat varieties to increased nitrogen levels was investigated...
2021-04-26 | MTBLS1801 | MetaboLights
MetabolomicsMetabolomics of red-light-induced stomatal opening in Arabidopsis thaliana: Coupling with abscisic acid and jasmonic acid metabolism
Environmental stimuli-triggered stomatal movement is a key physiological process that regulates CO2 uptake and water loss in plants. Stomata are defined by pairs of guard cells that perceive and transduce external signals, leading to cellular volume changes and consequent stomatal apertur...
2022-01-21 | MTBLS1326 | MetaboLights
TranscriptomicsExpression Differences in Ethanol Stress Response Between Saccharomyces cerevisiae Parent W303-1A Strain and its Two Ethanol Tolerant Mutants
Saccharomyces spp. are widely used for ethanol production however fermentation productivity is negatively affected by the impact of ethanol accumulation on yeast metabolic rate and viability. This study used microarray and statistical two-way ANOVA analysis to compare and evaluate gene expression pr...
ORGANISM(S): Saccharomyces cerevisiae 
2010-07-01 | E-GEOD-21120 | biostudies-arrayexpress
TranscriptomicsSaccharomyces cerevisiae transcriptome analysis of conditional yjr141w-psd mutant compared to control strain
The experiment investigates the consequences of Yjr141w downregulation on gene expression in yeast. The essential protein Yjr141w was depleted from cells using a tagged variant (Yjr141w-psd). The photo-sensitive degron (psd) module initiates degradation of the tag and its associated protein upon blu...
ORGANISM(S): Saccharomyces cerevisiae 
2018-03-18 | E-MTAB-5022 | biostudies-arrayexpress
TranscriptomicsAnalysis of wildtype and Xbp1-deficient hematopoietic progenitor cell transcriptomes
Purpose: The goals of this study are to assess the transcriptional networks governed by the transcription factor XBP1 in lineage-uncommitted myeloid progenitors and in eosinophil-committed myeloid progenitors. Methods: mRNA profiles of FACS-purified granulocyte-macrophage progenitors (GMPs) from X...
ORGANISM(S): Mus musculus 
2015-07-06 | E-GEOD-65753 | biostudies-arrayexpress
TranscriptomicsExpression data from low fluid shear cultured Staphylococcus aureus
The opportunistic pathogen, Staphylococcus aureus, encounters a wide variety of fluid shear levels within the human host, which may play a key role in dictating whether this organism adopts a commensal interaction with the host or transitions to cause disease. Using rotating-wall vessel bioreactors...
ORGANISM(S): Staphylococcus aureus subsp. aureus N315 
2011-05-31 | E-GEOD-28077 | biostudies-arrayexpress
TranscriptomicsMLL2 facilitates long-range gene regulation through LINE1 elements [scRNA-seq]
Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 deposition at bivalent promoters, which has been proposed to facilitate the induction of major develo...
ORGANISM(S): Mus musculus 
2026-07-12 | E-MTAB-17228 | biostudies-arrayexpress
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