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TranscriptomicsLow input Hi-C datasets for a diffuse large B-cell lymphoma sample, healthy control human B-cells and mouse embryonic stem cells
In this experiment, we've examined chromatin conformation of OG2 (B6; CBA-Tg(Pou5f1-EGFP)2Mnn/J; stock number 004654) mouse stem cells cultured as described in (Shi et al., 2008), using different amounts of starting cells. We performed a modified in situ Hi-C protocol for 6 samples digested with Mbo...
ORGANISM(S): Mus musculus 
2018-11-30 | E-MTAB-5875 | biostudies-arrayexpress
TranscriptomicsMLL2 facilitates long-range gene regulation through LINE1 elements [Micro-C]
Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 deposition at bivalent promoters, which has been proposed to facilitate the induction of major develo...
ORGANISM(S): Mus musculus 
2025-10-23 | E-MTAB-15688 | biostudies-arrayexpress
Genomicsc-Jun Targets Cockayne Syndrome protein B to Specific Genomic Region for Transcription Regulation
Cockayne syndrome is an inherited premature aging syndrome associated with developmental and neurological disorders. Mutations in the genomic locus encoding CSB are associated with 80% Cockayne syndrome cases. Transcription profiling assays reveal the association of mis-regulation of gene expressi...
ORGANISM(S): Homo sapiens 
2014-03-06 | E-GEOD-50171 | biostudies-arrayexpress
GenomicsBromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma (ChIP-Seq)
Pharmacological inhibition of chromatin co-regulatory factors represents a clinically validated strategy to modulate oncogenic signaling through selective attenuation of gene expression. Here, we demonstrate that CBP/EP300 bromodomain inhibition preferentially abrogates the viability of multiple mye...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-71909 | biostudies-arrayexpress
UnknownFragmentation of Care after Surgical Discharge: Non-Index Readmission after Major Cancer Surgery.
Not available
S-EPMC5244824 | biostudies-literature
GenomicsGenetic and epigenetic determinants of neurogenesis and myogenesis [ChIP-seq]
The regulatory networks of differentiation programs have been partly characterized; however, the molecular mechanisms of lineage-specific gene regulation by highly similar transcription factors remain largely unknown. Here we compare the genome-wide binding and transcription profiles of NEUROD2-medi...
ORGANISM(S): Mus musculus 
2012-03-26 | E-GEOD-34906 | biostudies-arrayexpress
UnknownCCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk.
Not available
S-EPMC9117519 | biostudies-literature
TranscriptomicsChanges in microRNA and mRNA expression with differentiation of human bronchial epithelial cells
This SuperSeries is composed of the following subset Series: GSE39059: Changes in microRNA and mRNA expression with differentiation of human bronchial epithelial cells [mRNA] GSE39060: Changes in microRNA and mRNA expression with differentiation of human bronchial epithelial cells [miRNA] Refer to i...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-39061 | biostudies-arrayexpress
TranscriptomicsChanges in microRNA and mRNA expression with differentiation of human bronchial epithelial cells [mRNA]
Normal human bronchial epithelial (NHBE) cells cultured in an air-liquid interface (ALI) system form a polarized, pseudostratified epithelium composed of basal, ciliated and goblet cells that closely resemble the in vivo airway epithelium structure. ALI cultures of NHBE cells provide a unique in vit...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-39059 | biostudies-arrayexpress
TranscriptomicsChanges in microRNA and mRNA expression with differentiation of human bronchial epithelial cells [miRNA]
Normal human bronchial epithelial (NHBE) cells cultured in an air-liquid interface (ALI) system form a polarized, pseudostratified epithelium composed of basal, ciliated and goblet cells that closely resemble the in vivo airway epithelium structure. ALI cultures of NHBE cells provide a unique in vit...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-39060 | biostudies-arrayexpress
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