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TranscriptomicsSplitting Function enables Dual Feedback Regulation to Control JAK2/STAT5 Signaling for a Wide Ligand Range
Cellular signal transduction is governed by multiple feedback mechanisms to elicit robust cellular decisions. We combined mathematical modeling and extensive time-resolved data sets in primary erythroid progenitor cells and dissected the roles of the two transcriptional feedback regulators of the S...
ORGANISM(S): Mus musculus 
2011-06-30 | E-GEOD-26151 | biostudies-arrayexpress
TranscriptomicsBiased transcription and selective degradation of small RNAs shape the pattern of DNA elimination in Tetrahymena
The ciliated protozoan Tetrahymena undergoes extensive programmed DNA elimination when the germline micronucleus produces the new macronucleus during sexual reproduction. DNA elimination is epigenetically controlled by DNA sequences of the parental macronuclear genome, and this epigenetic regulation...
ORGANISM(S): Tetrahymena thermophila 
2012-06-21 | E-GEOD-38768 | biostudies-arrayexpress
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