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MetabolomicsAngiopoietin-like 4 governs diurnal lipoprotein lipase activity in brown adipose tissue.

OBJECTIVE: Brown adipose tissue (BAT) burns fatty acids (FAs) to produce heat, and shows diurnal oscillation in glucose and triglyceride (TG)-derived FA-uptake, peaking around wakening. Here we aimed to gain insight in the diurnal regulation of metabolic BAT activity.

2023-11-15 | MTBLS4082 | MetaboLights
TranscriptomicsOverexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity
Aims/hypothesis: While lipid deposition in skeletal muscle is considered to be involved in obesity-associated insulin resistance, neutral intramyocellular lipid (IMCL) accumulation per se does not necessarily induce insulin resistance. We previously demonstrated that overexpression of the lipid drop...
ORGANISM(S): Rattus norvegicus 
2013-01-29 | E-GEOD-43832 | biostudies-arrayexpress
TranscriptomicsDetailed transcriptomics analysis of the effect of dietary fatty acids on gene regulation in the murine heart.
Fatty acids comprise the primary energy source for the heart and are mainly taken up via hydrolysis of circulating triglyceride-rich lipoproteins. While most of the fatty acids entering the cardiomyocyte are oxidized, a small portion is involved in altering gene transcription to modulate cardiometab...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-30495 | biostudies-arrayexpress
TranscriptomicsDetailed transcriptomics analysis of the effect of the PPARalpha agonist Wy14,643 on gene regulation in the murine heart
Fatty acids comprise the primary energy source for the heart and are mainly taken up via hydrolysis of circulating triglyceride-rich lipoproteins. While most of the fatty acids entering the cardiomyocyte are oxidized, a small portion is involved in altering gene transcription to modulate cardiometab...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-30553 | biostudies-arrayexpress
TranscriptomicsComparative transcriptomics and metabolomic analysis of fenofibrate and fish oil treatments in mice
Elevated circulating triglycerides, which are considered a risk factor for cardiovascular disease, can be targeted by treatment with fenofibrate or fish oil. To gain insight into underlying mechanisms, we carried out a comparative transcriptomics and metabolomics analysis of the effect of 2 week tre...
ORGANISM(S): Mus musculus 
2011-10-07 | E-GEOD-32706 | biostudies-arrayexpress
TranscriptomicsAdipocyte XBP1s regulates systemic insulin sensitivity by modulating adiponectin multimerization
The physiological role of the spliced form of X-box-binding protein 1 (XBP1s), a key transcription factor of the endoplasmic reticulum (ER) stress response, in adipose tissue remains largely unknown. Here we show that overexpression of XBP1s promotes adiponectin multimerization in adipocytes, thereb...
ORGANISM(S): Mus musculus 
2013-11-21 | E-GEOD-36031 | biostudies-arrayexpress
TranscriptomicsmRNA profiling reveals divergent roles of PPARa and PPARÃ?/d in regulating mouse liver gene expression (PPARa samples)
Little is known about the role of the transcription factor PPARÃ?/d in liver. Here we set out to better elucidate the function of PPARÃ?/d in liver by comparing the effect of PPARa and PPARÃ?/d deletion using whole genome transcriptional profiling and analysis of plasma and liver metabolites. In fed...
ORGANISM(S): Mus musculus 
2010-06-21 | E-GEOD-17863 | biostudies-arrayexpress
TranscriptomicsPPARγ activation promotes infiltration of alternatively activated macrophages into adipose tissue.
Background: Obesity is associated with infiltration of macrophages into adipose tissue. Adipose macrophages may contribute to an elevated inflammatory status by secreting a variety of pro-inflammatory mediators, including TNFalpha and IL-6. Recent data suggest that during diet-induced obesity the ph...
ORGANISM(S): Mus musculus 
2008-04-29 | E-GEOD-11295 | biostudies-arrayexpress
TranscriptomicsEicosapentaenoic acid improves metabolic switching in human myotubes
Metabolically healthy skeletal muscle is characterized by the ability to switch easily between glucose and fat oxidation, whereas loss of this ability seems to be related to insulin resistance. The aim of this study was to investigate whether different fatty acids (FAs) and the LXR ligand T0901317 a...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-18589 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human and mouse hepatocytes to perform a comparative analysis of gene regulation by the transcription factor PPARI?_mouse
Studies in mice have shown that PPARα is an important regulator of hepatic lipid metabolism and the acute phase response. However, little information is available on the role of PPARα in human liver. Here we set out to compare the function of PPARα in mouse and human hepatocytes via analysis of t...
ORGANISM(S): Mus musculus 
2009-09-25 | E-GEOD-17250 | biostudies-arrayexpress
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