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UnknownA thesaurus of genetic variation for interrogation of repetitive genomic regions.
Not available
S-EPMC4446415 | biostudies-literature
UnknownGain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity.
Not available
S-EPMC5010247 | biostudies-literature
UnknownA novel plant gene essential for meiosis is related to the human CtIP and the yeast COM1/SAE2 gene.
Not available
S-EPMC2140101 | biostudies-literature
UnknownA chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer.
Not available
S-EPMC3306898 | biostudies-literature
ProteomicsA common cell state in Triple Negative Breast Cancers can be targeted through inhibition of Spleen Tyrosine Kinase (SYK)
Breast tumors are highly heterogeneous and for many molecular subtypes no targeted therapies are available. These include breast cancers that display hallmarks of epithelial to mesenchymal transition (EMT), a process related to metastasis and enriched in triple negative breast cancers (TNBCs). To de...
ORGANISM(S): Homo sapiens (Human) 
2016-06-15 | PXD001680 | Pride
Syk inhibition Phosphotyrosine proteomics Human breast cancer 
TranscriptomicsNOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation
Breast cancer is genetically heterogeneous, and recent studies have underlined a prominent contribution of epigenetics to the development of this disease. To uncover new synthetic lethalities with known breast cancer oncogenes, we screened an epigenome-focused short hairpin RNA library on a panel...
ORGANISM(S): Homo sapiens 
2014-11-21 | E-GEOD-61727 | biostudies-arrayexpress
UnknownMutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks.
Not available
S-EPMC2838540 | biostudies-literature
UnknownTargeting a cell state common to triple-negative breast cancers.
Not available
S-EPMC4358660 | biostudies-literature
UnknownMEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated.
Not available
S-EPMC5150652 | biostudies-literature
UnknownA reversible gene trap collection empowers haploid genetics in human cells.
Not available
S-EPMC6342250 | biostudies-literature
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