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TranscriptomicsSaturated fat stimulates obesity and hepatic steatosis and affects gut microbiota composition by an enhanced overflow of dietary fat to the distal intestine
We studied the effect of dietary fat type, varying in polyunsaturated/saturated fatty acid ratio's (P/S) on development of metabolic syndrome. C57Bl/6J mice were fed purified high-fat diets (45E% fat) containing palm oil (HF-PO; P/S 0.4), olive oil (HF-OO; P/S 1.1) or safflower oil (HF-SO; P/S 7.8) ...
ORGANISM(S): Mus musculus 
2012-06-17 | E-GEOD-18586 | biostudies-arrayexpress
TranscriptomicsPPARγ activation promotes infiltration of alternatively activated macrophages into adipose tissue.
Background: Obesity is associated with infiltration of macrophages into adipose tissue. Adipose macrophages may contribute to an elevated inflammatory status by secreting a variety of pro-inflammatory mediators, including TNFalpha and IL-6. Recent data suggest that during diet-induced obesity the ph...
ORGANISM(S): Mus musculus 
2008-04-29 | E-GEOD-11295 | biostudies-arrayexpress
TranscriptomicsStructural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice [Small Intestine data]
By regulating digestion and absorption of nutrients and providing a barrier against the external environment the intestine provides a crucial contribution to the maintenance of health. To what extent aging-related changes in the intestinal system contribute to the impaired health of the aging body i...
ORGANISM(S): Mus musculus 
2012-09-03 | E-GEOD-39974 | biostudies-arrayexpress
TranscriptomicsStructural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice [Colon data]
By regulating digestion and absorption of nutrients and providing a barrier against the external environment the intestine provides a crucial contribution to the maintenance of health. To what extent aging-related changes in the intestinal system contribute to the impaired health of the aging body i...
ORGANISM(S): Mus musculus 
2012-09-03 | E-GEOD-39973 | biostudies-arrayexpress
TranscriptomicsKupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity.
Kupffer cells have been implicated in the pathogenesis of various liver diseases. However, their involvement in metabolic disorders of the liver, including fatty liver disease, remains unclear. The present study sought to determine the impact of Kupffer cells on hepatic triglyceride storage and to e...
ORGANISM(S): Mus musculus 
2011-10-17 | E-GEOD-33044 | biostudies-arrayexpress
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