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TranscriptomicsImmune Response of Immature Dendritic Cells after Infection with Human Cytomegalovirus Strain TB40E
Microarray analysis and quantitative real-time PCR revealed that TB40E infection of DCs led to changes of the gene expression pattern. A variety of pro-inflammatory cytokines and chemokines (CXCL10, CXCL11, CCL5), TLR3 and genes whose products function downstream of the TLR3 signalling pathway (e.g....
ORGANISM(S): Homo sapiens 
2009-08-01 | E-GEOD-14816 | biostudies-arrayexpress
ProteomicsProteomic characterization of cerebrospinal fluid in patients with brain malignancies
Recent technological advances in molecular diagnostics through liquid biopsies hold the promise to monitor tumor evolution and treatment response of brain malignancies without the need of invasive surgical tissue accrual. Here, we implemented a new mass spectrometry-based protein analysis pipeline a...
ORGANISM(S): Homo sapiens (Human) 
2021-03-25 | PXD021984 | Pride
Brain tumor Glioblastoma Proteome Biomarker 
ProteomicsCerebrospinal fluid proteomic profiling in nusinersen-treated patients with spinal muscular atrophy Cerebrospinal fluid proteomic profiling in nusinersen-treated patients with spinal muscular atrophy
Promising results from recent clinical trials on the approved antisense oligonucleotide nusinersen in pediatric patients with 5q-linked spinal muscular atrophy (SMA) still have to be confirmed in adult patients but are hindered by a lack of sensitive biomarkers that indicate an early therapeutic res...
ORGANISM(S): Homo sapiens (Human) 
2020-01-07 | PXD016757 | Pride
Mass spectrometry (ms) Proteomics Antisense oligonucleotide (aso) Nusinersen Spinal muscular atrophy (sma) Cerebrospinal fluid (csf) 
ProteomicsA clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1
Tumor microtubes (TMs) connect glioma cells to a network with considerable relevance for tumor progression and therapy resistance. The determination of TM-interconnectivity in individual tumors has been challenging and the impact on patient survival unresolved. Here, a connectivity signature from si...
ORGANISM(S): Homo sapiens (Human) 
2023-11-27 | PXD044001 | Pride
Gene expression signature Glioblastoma Connectivity Tumor microtubes Single-cell rna-sequencing 
UnknownDe novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population.
Not available
S-EPMC7007577 | biostudies-literature
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