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MetabolomicsUntargeted Metabolomics Reveals Molecular Effects of Ketogenic Diet on Healthy and Tumor Xenograft Mouse Models
The application of ketogenic diet (KD) (high fat/low carbohydrate/adequate protein) as an auxiliary cancer therapy is a field of growing attention. KD provides sufficient energy supply for healthy cells, while possibly impairing energy production in highly glycolytic tumor cells. Moreover, KD regula...
2019-10-08 | MTBLS1066 | MetaboLights
MetabolomicsInduction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer

Tumor-initiating cells (TICs) tend to reside in poorly vascularized regions of tumors and are subjected to nutrient stress. How TICs activate metabolic plasticity for adapting to periods of low nutrient availability, especially during glucose-limiting conditions, has remained unclarified. Here, w...

2025-09-29 | MTBLS8430 | MetaboLights
MetabolomicsEffect of ketogenic diet on the plasma and tumor metabolome of melanoma-bearing mice
Not available
ORGANISM(S): Mus musculus 
ST001903 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of mouse livers from animals fed a ketogenic diet (KD), a diet high in fat and low in carbohydrates
Analysis of liver gene transcription during feeding of a ketogenic diet. Ketogenic diets may alter physiologic and metabolic profiles in a direction that favors weight loss. C57BL/6J mice were maintained for six weeks on either chow or ketogenic diet. Mice eating KD had lower weights, 90% reduction...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-7699 | biostudies-arrayexpress
TranscriptomicsMyocardial expression data from ketogenic diet-fed mice
Specific pathogen free wild-type C57Bl/6 male mice fed ketogenic diet (Bio-Serv AIN-76-A) for 4 weeks Keywords: RNA Expression Array Hearts from 12 week-old mice that were maintained on a standard polysacchardide-rich chow until the age of 8 weeks, at which time they were switched to a ketogenic di...
ORGANISM(S): Mus musculus 
2010-06-16 | E-GEOD-21368 | biostudies-arrayexpress
ProteomicsIdentification of acetylated proteins in the hearts of mice fed a ketogenic diet
Diets influence metabolism and susceptibility to disease. We have previously demonstrated that a ketogenic diet alleviates cardiac pathology, with its cardioprotective effects linked to increased lysine acetylation in the heart. To identify acetylated proteins associated with this diet, we conducted...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-03 | PXD059855 | Pride
Heart Acetylation Ketogenic diet Hypertension 
ProteomicsKetogenic diet versus standard high-carbohydrate nutrition in sepsis: a randomized controlled trial
Rationale: Sepsis patients suffer from severe metabolic and immunologic dysfunction that may be amplified by standard carbohydrate-based nutritional regimes. We therefore hypothesize that a ketogenic diet improves sepsis treatment. Objectives: We investigated the safety and feasibility of a ketogeni...
ORGANISM(S): Homo sapiens (Human) 
2024-06-13 | PXD046061 | Pride
Nutritional medicine Inflammation Sepsis Intensive care Critically ill patients Ketogenic diet 
TranscriptomicsIntegrative Multi-Omics Reveal Metabolic Reprogramming by Ketogenic Diet in Melanoma Xenografts
The ketogenic diet (KD) has demonstrated anti-proliferative effects across multiple tumor types, yet the underlying metabolic and transcriptomic mechanisms remain incompletely understood. This study employed integrated multi-omics analysis combining targeted metabolomics and RNA-sequencing to elucid...
ORGANISM(S): Homo sapiens 
2026-07-01 | E-MTAB-16979 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat brain hippocampi of animals fed the ketogenic diet (KD) to provide insight into the anticonvulsant action of KD
The ketogenic diet (KD) is an anticonvulsant treatment that has been used to manage medically-intractable epilepsies. The KD requires 10-12 days to become maximally effective, suggesting that changes in gene expression are involved in its anticonvulsant action. Using the Affymetrix rat arrays (RAE...
ORGANISM(S): Rattus norvegicus 
2007-10-27 | E-GEOD-1155 | biostudies-arrayexpress
TranscriptomicsKainic acid-administered Rat brain: control vs Ketogenic diet-fed
The ketogenic diet has long been used to treat epilepsy, but its mechanism is not yet clearly understood. To explore the potential mechanism, the changes in gene expression induced by the ketogenic diet in the rat kainic acid (KA) epilepsy model were analyzed. Two-condition experiment, Normal diet-f...
ORGANISM(S): Rattus norvegicus 
2010-05-19 | E-GEOD-19277 | biostudies-arrayexpress
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