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TranscriptomicsComprehensive profiling of the early lung immune responses in the mouse model of tuberculosis
The lung host immune responses following M.tuberculosis infection in the mouse model of tuberculosis were assayed by studying the gene expression profiles at day 0, day 12, 15 and 21 post infection Mice were infected with M.tuberculosis via the aerosol route and the host gene induction during early ...
ORGANISM(S): Mus musculus 
2010-07-21 | E-GEOD-23014 | biostudies-arrayexpress
TranscriptomicsUsv101 is a key regulator of cryptococcal virulence and determinant of host response
Cryptococcus neoformans is a fungal pathogen responsible for hundreds of thousands of deaths per year. Its critical virulence factor is a polysacharride capsule which grows large upon entry into a mammalian host. We previously identified USV101 as a transcription factor whose deletion results in enl...
ORGANISM(S): Cryptococcus neoformans 
2016-03-31 | E-GEOD-69532 | biostudies-arrayexpress
TranscriptomicsItaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation
Remodeling of the tricarboxylic acid (TCA) cycle is a metabolic adaptation mechanism accompanying inflammatory macrophage activation. During this process, endogenous metabolites can adopt regulatory roles that govern specific aspects of inflammatory response, as recently shown for succinate, which r...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-82043 | biostudies-arrayexpress
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