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Our experiments examine gene expression profiles from activated and tolerant CD4+ T cells of Tg4 TCR transgenic mice to discover differentially expressed genes with the aim of gaining new insights about the molecular and genetic basis underlying autoimmune disease.
ORGANISM(S): Mus musculus 
Methylated DNA immunoprecipitation followed by high-throughput sequencing (MeDIP-seq) has the potential to identify changes in DNA methylation important in cancer development. In order to understand the role of epigenetic modulation in the development of acute myeloid leukemia (AML) we have applied ...
ORGANISM(S): Homo sapiens 
We report the application of methylated DNA immunoprecipitation followed by next-generation sequencing to trisomy 8 AML. Through a global study and quantifying the methylation signals, we demonstrated a characteristic DNA methylation distribution for trisomy 8 indicating the impact of the hypermethy...
ORGANISM(S): Homo sapiens 
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