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TranscriptomicsStatistical analysis of differential gene expression relative to a fold change threshold on NanoString data of mouse odorant receptor genes
We developed a systematic statistical method, tTREAT, to identify differentially expressed genes with respect to a predefined FC threshold. The tTREAT approach aims to reduce false discoveries. We applied statistical tests relative to a Fold Change threshold to a dataset about mouse odorant receptor...
ORGANISM(S): Mus musculus 
2014-01-08 | E-GEOD-53876 | biostudies-arrayexpress
TranscriptomicsA family of nonclassical class I MHC genes contributes to ultrasensitive chemodetection by mouse vomeronasal sensory neurons
We applied the NanoString gene expression platform to total RNA isolated from the vomeronasal mucosa of mice of a strain (M-bM-^HM-^FH2Mv) in which we had excised with chromosome engineering a 530 kb genomic region that encompasses nine non-classical class I MHC genes that are expressed specifically...
ORGANISM(S): Mus musculus 
2014-04-09 | E-GEOD-54061 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-sequencing of OMP-GFP mouse olfactory sensory neurons
We sequenced the transcriptome of 34 single olfactory sensory neurons (OSNs) manually picked from OMP-GFP mice, ensuring the cells expressed high levels of GFP, a marker of mature OSNs. We pooled the olfactory mucosa from 2 male and 2 female animals, to obtain single-cell suspensions for cell pickin...
ORGANISM(S): Mus musculus 
2020-02-04 | E-MTAB-8285 | biostudies-arrayexpress
MetabolomicsEcological adaptation and succession of human fecal microbial communities in an automated in vitro fermentation system
Longitudinal studies of gut microbiota following specific interventions are vital for understanding how they influence host health. However, robust longitudinal sampling of gut microbial communities is a major challenge, which can be addressed using in vitro fermenters hosting complex microbial comm...
2021-07-15 | MTBLS2531 | MetaboLights
MetabolomicsPlot diversity differentially affects the chemical composition of leaves, roots and root exudates in four subtropical tree species

Plants produce thousands of compounds, collectively called the metabolome, which mediate interactions with other organisms. The metabolome of an individual plant may change according to the number and nature of these interactions. We tested the hypothesis that tree diversity level affects the met...

2021-08-09 | MTBLS1968 | MetaboLights
TranscriptomicsArray CGH analysis for 29 pancreatic ductal adenocarcinoma (PDAC) samples
Background/Aims: Microarray-based comparative genomic hybridisation (CGH) has allowed high-resolution analysis of DNA copy number alterations across the entire cancer genome. Recent advances in bioinformatics tools enable us to perform a robust and highly sensitive analysis of array CGH data and fac...
ORGANISM(S): Homo sapiens 
2008-12-16 | E-GEOD-9672 | biostudies-arrayexpress
TranscriptomicsEffects of sample size on differential gene expression, rank order and prediction accuracy of a gene signature
Gene expression profiles were generated from muscle biopsies from 134 individuals, and differences in expression based on sex were explored. Top differentially expressed gene lists are often inconsistent between studies and it has been suggested that small sample sizes contribute to lack of reprodu...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-41726 | biostudies-arrayexpress
UnknownBCG Revaccination for the Prevention of <i>Mycobacterium tuberculosis</i> Infection.
Not available
S-EPMC12061034 | biostudies-literature
UnknownThe association of spirometric small airways obstruction with respiratory symptoms, cardiometabolic diseases, and quality of life: results from the Burden of Obstructive Lung Disease (BOLD) study.
Not available
S-EPMC10207810 | biostudies-literature
GenomicsNational Cancer Institute (NCI) TARGET: Therapeutically Applicable Research to Generate Effective Treatments

The Therapeutically Applicable Research to Generate Effective Treatments (TARGET) Initiative seeks to accelerate research in novel marker and drug development, along with understanding the molecular basis of pediatric malignancy, through identification of genomic changes associated with the follo...

phs000218.v5.p1 | EGA
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