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TranscriptomicsA single cell transcriptome atlas of murine endothelial cells
The heterogeneity of endothelial cells (ECs), lining blood vessels, across tissues remains incompletely inventoried. We constructed an atlas of >32,000 single-EC transcriptomic data from 11 tissues of the model organism Mus musculus. We propose a new classification of EC phenotypes based on transcri...
ORGANISM(S): Mus musculus 
2020-02-13 | E-MTAB-8077 | biostudies-arrayexpress
TranscriptomicsClosing the mitochondrial permeability transition pore in hiPSC-derived endothelial cells induces glycocalyx formation and functional maturation.
Human induced pluripotent stem cells (hiPSCs) are used to study organogenesis and model disease as well as being developed for regenerative medicine. Endothelial cells are among the many cell types differentiated from hiPSC, but their maturation and stabilization fall short of that in adult endothel...
ORGANISM(S): Homo sapiens 
2019-12-14 | E-MTAB-8392 | biostudies-arrayexpress
TranscriptomicsHeterogeneous effects of calorie content and nutritional components underlie dietary influence over pancreatic cancer susceptibility in mice and humans
Pancreatic cancer is a rare but fatal form of cancer, the fourth highest in absolute mortality. The main reason for the high mortality is late detection, caused in part by an incomplete understanding of the initiating factors. Known risk factors include obesity, diet and type 2 diabetes, however the...
ORGANISM(S): Mus musculus 
2020-07-16 | E-MTAB-8227 | biostudies-arrayexpress
TranscriptomicsAn integrated approach to profile lung tumor endothelial cell heterogeneity across species and models and to identify angiogenic candidates
Heterogeneity of lung tumor endothelial cell (TEC) phenotypes across patients, species (human/mouse) and models (in vivo/vitro) remains poorly inventoried at the single-cell-level. We single-cell RNA-sequenced 56,771 ECs from human/mouse (peri)-tumoral lung and cultured human lung TECs, detected 17 ...
ORGANISM(S): Homo sapiens 
2020-03-07 | E-MTAB-8031 | biostudies-arrayexpress
TranscriptomicsAn integrated approach to profile lung tumor endothelial cell heterogeneity across species and models and to identify angiogenic candidates
Heterogeneity of lung tumor endothelial cell (TEC) phenotypes across patients, species (human/mouse) and models (in vivo/vitro) remains poorly inventoried at the single-cell-level. We single-cell RNA-sequenced 56,771 ECs from human/mouse (peri)-tumoral lung and cultured human lung TECs, detected 17 ...
ORGANISM(S): Mus musculus 
2020-05-20 | E-MTAB-7458 | biostudies-arrayexpress
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