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UnknownThe effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study.

Background

One of the most robust genetic associations for cardiovascular disease (CVD) is the Chromosome 9p21 region. However, the interaction of this locus with environmental factors has not been extensively explored. We investigated the association of 9p21 with myocardial infarction (MI) ...
S-EPMC3191151 | biostudies-literature
UnknownLaparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.

Background

Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgi...
S-EPMC6061087 | biostudies-literature
UnknownGlobal economic burden of unmet surgical need for appendicitis.

Background

There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis.

Methods

Data on the incidence of appendicitis from 1...
S-EPMC10364778 | biostudies-literature
UnknownDeterminants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries.

Background

Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries ...
S-EPMC5321375 | biostudies-literature
UnknownGlobal variation in anastomosis and end colostomy formation following left-sided colorectal resection.

Background

End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.

Metho...

S-EPMC6921967 | biostudies-literature
UnknownElective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries.

Background

The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planni...
S-EPMC9621702 | biostudies-literature
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