Sort   by:  
 Page size 
ModelsKholodenko2000 - Ultrasensitivity and negative feedback bring oscillations in MAPK cascade
Kholodenko2000 - Ultrasensitivity and negative feedback bring oscillations in MAPK cascade The combination of ultrasensitivity and negative feedback bring sustained oscillations in the mitogen-activated protein kinase cascades. This model is descr...
2024-09-02 | BIOMD0000000010 | BioModels
ModelsKholodenko1999 - EGFR signaling
Kholodenko1999 - EGFR signaling This model has been generated by the JWS Online project by Jacky Snoep using PySCeS Run this model online at http://jjj.biochem.su...
2024-09-02 | BIOMD0000000048 | BioModels
ModelsOrtega2006 - bistability from double phosphorylation in signal transduction
Ortega2006 - bistability from double phosphorylation in signal transduction This model is described in the article: Bistability from double phosphorylation in signal transduction. Kinetic and structural requirements. Ortega F, Ga...
2024-09-02 | BIOMD0000000258 | BioModels
ModelsMarkevich2004_MAPK_orderedMM2kinases
The model describes the double phosphorylation of MAP kinase by an ordered mechanism using the Michaelis-Menten formalism. Two different enzymes, MAPKK1 and MAPKK2, successively phosphorylate the MAP kinase, but one and the same phosphatase dephosphorylates both sites. The model repr...
2024-09-02 | BIOMD0000000031 | BioModels
ModelsMarkevich2004_MAPK_phosphoRandomElementary
The model corresponds to the schema 3 of Markevich et al 2004, as described in the figure 2 and the supplementary table S2. Phosphorylations follow distributive random kinetics, while dephosphorylations follow an ordered mechanism. The phosphorylations are modeled with three elementary reactions: ...
2024-09-02 | BIOMD0000000028 | BioModels
ModelsNguyen2016 - Feedback regulation in cell signalling: Lessons for cancer therapeutics
Feedback regulation in cell signalling: Lessons for cancer therapeutics This model is described in the article: Feedback regulation in cell signalling: Lessons for cancer...
2024-09-02 | BIOMD0000000651 | BioModels
ProteomicsPhosphoproteomics of TrkA and TrkB signaling in SH-SY5Y neuroblastoma cells
Human neuroblastoma cells (SH-SY5Y) were engineered to have stable expression of either TrkA (NTRK1) or TrkB (NTRK2) receptors. The cells were pretreated with 0.5 μM Trametinib, 2.5 μM Gefitinib, and combination of 0.25 μM Trametinib and 1.25 μM Gefitinib. Stimulation of TrkA and TrkB-expressing SH-...
ORGANISM(S): Homo sapiens (Human) 
2022-04-13 | PXD028943 | Pride
Phosphoproteomics Neuroblastoma. 
ModelsMarkevich2004 - MAPK double phosphorylation, ordered Michaelis-Menton
Markevich2004 - MAPK double phosphorylation, ordered Michaelis-Menton The model corresponds to the schemas 1 and 2 of Markevich et al 2004, as described in the figure 1 and modelled using Michaelis-Menten like kinetics. Phosphorylations and dephosphorylations follow distributive ordered kinetics. It...
2024-09-02 | BIOMD0000000027 | BioModels
ModelsReiterer2013 - pseudophosphatase STYX role in ERK signalling
Reiterer2013 - pseudophosphatase STYX role in ERK signalling This model is described in the article: Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2. Reiterer V, Fey D, Kolch W, Kholodenko BN, Farhan H. Proc. N...
2024-09-02 | BIOMD0000000557 | BioModels
ModelsNguyenLK2011 - Ubiquitination dynamics in Ring1B/Bmi1 system
NguyenLK2011 - Ubiquitination dynamics in Ring1B-Bmi1 system This theoretical model investigates the dynamics of Ring1B/Bmi1 ubiquitination to identify bistable switch-like and oscillatory behaviour in the system. Michaelis-Menten (MM) equations are used to formulate the model. However, the authors ...
2024-09-02 | BIOMD0000000622 | BioModels
Sort   by:  
 Page size