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TranscriptomicsAffymetrix SNP array data for low-grade astrocytoma samples
Copy number analysis of 21 paediatric low-grade astrocytomas identified a discrete copy number gain of 1.9Mb in chromosome band 7q34. The gain was present in 12/14 cerebellar pilocytic astrocytomas. Subsequent analysis of tumour cDNA indentified a novel gene fusion between KIAA1549 and BRAF in these...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-14960 | biostudies-arrayexpress
UnknownConditional KIAA1549:BRAF mice reveal brain region- and cell type-specific effects.
Not available
S-EPMC3808469 | biostudies-literature
UnknownDetection of the KIAA1549-BRAF fusion gene in cells forming microvascular proliferations in pilocytic astrocytoma.
Not available
S-EPMC6645544 | biostudies-literature
UnknownKIAA1549: BRAF Gene Fusion and FGFR1 Hotspot Mutations Are Prognostic Factors in Pilocytic Astrocytomas.
Not available
S-EPMC4470527 | biostudies-literature
UnknownWhole Chromosome 7 Gain Predicts Higher Risk of Recurrence in Pediatric Pilocytic Astrocytomas Independently From KIAA1549-BRAF Fusion Status.
Not available
S-EPMC5009478 | biostudies-literature
GenomicsMulti-omics Dissection of MAPK-driven Senescence Unveils Therapeutic Vulnerabilities in KIAA1549::BRAF-fusion Pediatric Low-Grade Glioma Models
Multi-omics Dissection of MAPK-driven Senescence Unveils Therapeutic Vulnerabilities in KIAA1549::BRAF-fusion Pediatric Low-Grade Glioma Models
PRJNA1213793 | ENA
UnknownBRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants.
Not available
S-EPMC4629834 | biostudies-literature
UnknownEstablishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing.
Not available
S-EPMC5355278 | biostudies-literature
TranscriptomicsMulti-omics Dissection of MAPK-driven Senescence Unveils Therapeutic Vulnerabilities in KIAA1549::BRAF-fusion Pediatric Low-Grade Glioma Models
Pilocytic astrocytomas (PA), the most common pediatric low-grade gliomas (pLGGs), are characterized by genetic MAPK pathway alterations leading to constitutive activation and oncogene-induced senescence (OIS) accompanied with the senescence-associated secretory phenotype (SASP). This study investiga...
ORGANISM(S): Homo sapiens 
2025-06-24 | GSE287599 | GEO
UnknownKIAA1549-BRAF Expression Establishes a Permissive Tumor Microenvironment Through NFκB-Mediated CCL2 Production.
Not available
S-EPMC6277251 | biostudies-literature
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