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TranscriptomicsA Genome-wide DNA Methylation Study in Colorectal Carcinoma
Genome wide DNA methylation profiling of tumor and surrounding healthy colonic mucosa from patients with colorectal carcinoma. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across 27,578 CpG loci covering 14,475 genes. Samples included a to...
ORGANISM(S): Homo sapiens 
2012-05-22 | E-GEOD-29490 | biostudies-arrayexpress
TranscriptomicsFeasibility and Interpretation of the Genome-wide Infinium Methylation Data Derived from Ligated Formalin Fixed Paraffin Embedded Paired Tumor and Normal Tissue.
Formalin-fixed paraffin-embedded (FFPE) samples are a highly desirable resource for epigenetic studies, but there is no suitable platform to assay genome-wide methylation in these widely available resources. Recently, Thirwell et al. (2010) have reported a modified ligation-based DNA repair protocol...
ORGANISM(S): Homo sapiens 
2014-10-23 | E-GEOD-33181 | biostudies-arrayexpress
TranscriptomicsA Genome-wide Study of Cytogenetic Changes in Colorectal Cancer Using SNP Microarrays: Possibilities for Future Personalized Treatment
In colorectal cancer (CRC), chromosomal instability (CIN) is typically studied using comparative-genomic hybridization (CGH) arrays. We studied paired (tumor and surrounding healthy) fresh-frozen tissue from 86 CRC patients using Illumina’s Infinium-based SNP array. This method allowed us to study C...
ORGANISM(S): Homo sapiens 
2014-12-19 | E-GEOD-34678 | biostudies-arrayexpress
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