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MetabolomicsUntargeted gas chromatography–mass spectrometry-based metabolomics analysis of kidney and liver tissue from the Lewis Polycystic Kidney rat
Polycystic kidney disease (PKD) encompasses a spectrum of inherited disorders that lead to end-stage renal disease (ESRD). There is no cure for PKD and current treatment options are limited to renal replacement therapy and transplantation. A better understanding of the pathobiology of PKD is needed ...
2023-01-26 | MTBLS748 | MetaboLights
ProteomicsData-Independent Acquisitions Uncover Kidney Proteome Remodeling during Ischemic Reperfusion Kidney Injury using a Fast-scanning ZenoTOF 7600
Acute kidney injury (AKI) manifests as a major health concern particularly for the elderly and understanding related proteome changes is critical for prevention and development of novel therapeutics to recover kidney function, and to mitigate the susceptibility for recurrent AKI, or development of c...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-11-23 | MSV000090777 | MassIVE
TranscriptomicsGene expression analysis of cultured rat primary proximal tubular cells (PTC) after isolation and differentiation
The aim of this study is to evaluate the transcripitomics changes during dedifferentiation up to 7 days in a transwell system of rat primary proximal tubular cell (PTC) cultures isolated from rat kidneys. Samples were taken from freshly isolated PTC (0 days) and at timeponts during PTC differentiati...
ORGANISM(S): Rattus norvegicus 
2024-06-30 | E-MTAB-13633 | biostudies-arrayexpress
MetabolomicsKidney Tissue Targeted Metabolic Profiling of Unilateral Ureteral Obstruction Rats by NMR
Renal interstitial fibrosis is a common pathological process in the progression of kidney disease. A nuclear magnetic resonance (NMR) based metabolomics approach was used to analyze the kidney tissues of renal interstitial fibrosis (RIF) rats, induced by unilateral ureteral obstruction (UUO). The co...
2017-10-09 | MTBLS361 | MetaboLights
ProteomicsGlobal proteome and phosphoproteome characterization of sepsis-induced kidney injury
Sepsis-induced acute kidney injury (S-AKI) is the most common complication in hospitalized and critically ill patients, highlighted by a rapid decline of kidney function occurring a few hours or days after sepsis onset. Systemic inflammation elicited by microbial infections is believed to lead to ki...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000086126 | MassIVE
TranscriptomicsGene Expression of Kidney from HSRA-S (congenital solitary kidney) and HSRA-C (two-kidney) using Rat Gene 1.1 ST Array [RaGene-1_1-st]
We recently developed a new model of renal agenesis [i.e., the heterogeneous stock derived model of unilateral renal agenesis, (HSRA)]. The HSRA model consistently exhibits unilateral renal agenesis ranging from 50-75% in each generation and is characterized by low nephron number, early kidney hyper...
ORGANISM(S): Rattus norvegicus 
2014-10-07 | E-GEOD-62092 | biostudies-arrayexpress
ProteomicsFibroblast-derived Smoothened governs prognosis of acute kidney injury
Although the tubule is the epicenter of damage, kidney fibroblast is increasingly appreciated in governing the prognosis of acute kidney injury (AKI). Smoothened (Smo), a heptahelical transmembrane protein, carries a hedgehog signal to mediate the communications between kidney fibroblasts and tubula...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-12-23 | MSV000088609 | MassIVE
TranscriptomicsMolecular changes in kidney allografts after simultaneous liver-kidney compared with solitary kidney transplantation
The aim of this study was to investigate correlations between early subclinical findings (10 and 90 day histology and gene expression data) and late outcomes (transplant glomerulopathy and graft loss) in positive crossmatch kidney transplants (+XMKTx). Our goal was threefold: first, to confirm that ...
ORGANISM(S): Homo sapiens 
2017-04-14 | E-GEOD-97780 | biostudies-arrayexpress
TranscriptomicsThe Aryl Hydrocarbon Receptor Regulates Tissue-Specific Dioxin-Dependent and Dioxin-Independent Gene Batteries: Kidney
The aryl hydrocarbon receptor (AHR) is a widely-expressed ligand-dependent transcription-factor that mediates cellular responses to dioxins and other planar aromatic hydrocarbons. Indeed, AHR-null mice are refractory to the physiological effects of dioxin-exposure. Although some mechanistic aspects ...
ORGANISM(S): Mus musculus 
2009-09-21 | E-GEOD-15857 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing identifies Cdh11 and Mrc1 as novel translational biomarkers of kidney fibrosis
Chronic kidney disease (CKD) is the gradual, asymptomatic loss of kidney function and current tests only identify it when significant loss has already happened. Using RNA sequencing in a mouse model of folic acid (FA) induced nephropathy, here we report the identification of 10 genes that track kidn...
ORGANISM(S): Mus musculus 
2015-10-23 | E-GEOD-65267 | biostudies-arrayexpress
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