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TranscriptomicsGene expression profiles of amiodarone, valproic acid, and tetracycline induced steatosis in C57BL/6 mice
Toxicogenomics (tgx) is used as a tool to identify mechanisms and markers of steatosis in C57BL/6 mice treated by oral gavage using amiodarone (AMD), valproic acid (VPA), and tetracycline (TET). Critical doses for tgx analysis were derived from a 25 day dose range finding study. For tgx analysis, l...
ORGANISM(S): Mus musculus 
2014-02-25 | E-GEOD-48126 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat primary hepatocytes after acetaminophen-induced gene expression in sandwich-culture
Gene expression profiles of sandwich-cutlured primary rat hepatocytes exposed to 5 mM and 10 mM acetaminophen were used in a parallelogram approach in order to compare gene expression responses between rat and human using in vitro cellular models, heaptocytes, and between rat in vitro and in vivo Ex...
ORGANISM(S): Rattus norvegicus 
2009-01-14 | E-GEOD-13465 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of acetaminophen, isoniazid, and paraquat treated C57BL/6 mice
Toxicogenomics (tgx) is used as a tool to identify mechanisms and markers of necrosis in C57BL/6 mice treated by oral gavage using acetaminophen (APAP), isoniazid (INZ), and paraquat (PQ). Critical doses for tgx analysis were derived from a 25 day dose range finding study. For tgx analysis, livers ...
ORGANISM(S): Mus musculus 
2014-12-16 | E-GEOD-51969 | biostudies-arrayexpress
TranscriptomicsGene expression profiles for onset and progression of Cyclosporin A-induced cholestasis in C57BL/6 mice
Mechanism-based toxicogenomics (tgx) is used as a tool to identify markers reflective of the onset and progression of cholestasis in C57BL/6 mice using Cyclosporin A (CsA) as a model compound. Critical doses for tgx analysis were derived from a dose range finding study in which increase of serum cho...
ORGANISM(S): Mus musculus 
2013-07-11 | E-GEOD-31540 | biostudies-arrayexpress
TranscriptomicsThe zebrafish embryo as an alternative model for the evaluation of liver toxicity using histopathology and expression profiling
The zebrafish is as a powerful vertebrate model system for modeling human disease including liver pathology. In ZFE, hepatic responses can be expected after exposure to hepatotoxicants, because hepatocytes are present from 36-hpf and at 72-hpf the liver is fully functioning. These characteristics ma...
ORGANISM(S): Danio rerio 
2015-05-15 | E-GEOD-38042 | biostudies-arrayexpress
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