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TranscriptomicsChanges in miR expression profile carotid plaques induced by acutely induced flow disturbances in apoe-/- mice on a high fat diet.
Atherosclerosis is causally related to disturbed flow through low and oscillatory shear stress. In order to study the miR expression profile in atherosclerotic plaques induced by disturbed flow, partial ligation of the carotid artery was performed. This procedure results acutely in severly reduced b...
ORGANISM(S): Mus musculus 
2012-12-26 | E-GEOD-26555 | biostudies-arrayexpress
TranscriptomicsMiR expression profiles in M1-polarized compared with unstimulated (MФ) bone marrow-derived macrophage cells
The global change of the miR expression profile during atherosclerosis is due to the infiltration of different types of leukocytes into the arterial vessel wall in addition to disease-specific regulation in vascular cells. Monocyte-derived macrophage accumulation in the subintimal region is critical...
ORGANISM(S): Mus musculus 
2012-12-26 | E-GEOD-33453 | biostudies-arrayexpress
TranscriptomicsIL-15 activates mTOR and primes stress-activated gene-expression leading to prolonged anti-tumor capacity of NK cells
Treatment of hematological malignancies by adoptive transfer of activated natural killer (NK) cells is limited by poor post-infusion persistence. We compared the ability of interleukin-2 (IL-2) and IL-15 to sustain human NK cell functions following cytokine withdrawal to model post-infusion performa...
ORGANISM(S): Homo sapiens 
2016-08-24 | E-GEOD-77808 | biostudies-arrayexpress
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